CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
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DOI：
10.1186/s12943-015-0317-1
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发表时间：
2015-02-18
期刊：
影响因子：
37.3
通讯作者：
Davidson B
中科院分区：
文献类型：
--
作者：
Nymoen DA;Holth A;Hetland Falkenthal TE;Tropé CG;Davidson B
本研究的目的是研究14个以前被证明与卵巢浆液性癌积液的化疗反应和/或无进展生存相关的基因在卵巢浆液性癌积液中的表达和临床作用。采用实时定量聚合酶链式反应检测晚期卵巢浆液性癌(n = 15 0)中AKR1C1C1AKR1C1ABCA4、ABCA13、ABCB10、BIRC6、CASP9、CIAPIN1、Fas、MGMT、MUTYH、POLH、SRC、TBRKB和XPAmRNA的表达。研究信使核糖核酸表达与临床病理参数的关系，包括化疗反应和生存期。在整个队列中，ABCA4mRNA的表达与确诊时较好的(完全)化疗反应显著相关(p = 0.018)，而在对58例接受标准化疗(卡铂 + 紫杉醇；p = 0.023)治疗的化疗前积液患者的分析中，较高的POLHmRNA水平与较好的确诊化疗反应显著相关。在化疗前积液患者(n = 77)的单因素生存分析中，CIAPIN1mRNA的表达与总生存期(p = 0.007)和无进展生存期(p = 0.038)显著相关，而ABCA13m RNA的表达与OS(p = 0.024)显著相关。在COX多因素分析中，CIAPIN1mRNA的高表达是总生存率较低的独立标志(p = 0.044)。我们的数据证实ABCA4和POLH是转移性浆液性癌较好的化疗反应的标志物。CIAPIN1和ABCA13可能是化疗前浆液性癌积液预后不良的新标记物。
The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ovarian serous carcinoma effusions. Advanced-stage serous ovarian carcinoma effusions (n = 150) were analyzed for mRNA expression of AKR1C1, ABCA4, ABCA13, ABCB10, BIRC6, CASP9, CIAPIN1, FAS, MGMT, MUTYH, POLH, SRC, TBRKB and XPA using quantitative real-time PCR. mRNA expression was studied for association with clinicopathologic parameters, including chemotherapy response and survival. ABCA4 mRNA expression was significantly related to better (complete) chemotherapy response at diagnosis in the entire cohort (p = 0.018), whereas higher POLH mRNA levels were significantly related to better chemoresponse at diagnosis in analysis to 58 patients with pre-chemotherapy effusions treated with standard chemotherapy (carboplatin + paclitaxel; p = 0.023). In univariate survival analysis for patients with pre-chemotherapy effusions (n = 77), CIAPIN1 mRNA expression was significantly related to shorter overall (p = 0.007) and progression-free (p = 0.038) survival, whereas ABCA13 mRNA expression was significantly related to shorter OS (p = 0.024). Higher CIAPIN1 mRNA expression was an independent marker of poor overall survival in Cox multivariate analysis (p = 0.044). Our data identify ABCA4 and POLH as markers of better chemotherapy response in metastatic serous carcinoma. CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions.
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