Effects of diabetes and obesity on cognitive impairment and mortality in older mexicans.
Effects of diabetes and obesity on cognitive impairment and mortality in older mexicans.
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DOI：
10.1016/j.archger.2021.104581
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发表时间：
2022-03
影响因子：
4
通讯作者：
Wong R
中科院分区：
文献类型：
--
作者：
Milani SA;Lopez DS;Downer B;Samper-Ternent R;Wong R
糖尿病是痴呆和死亡的危险因素，而晚年肥胖则与风险降低有关。他们的共同出现，糖尿病，是常见的，但其与痴呆症和死亡率的关系尚不清楚。使用来自墨西哥健康和老龄化研究的数据，我们使用多项逻辑回归来检查2012年糖尿病和体重指数（BMI）以及糖尿病肥胖与2018年认知障碍和死亡率的相关性，这些参与者年龄≥60岁，基线认知正常（n= 7，885）。与未患糖尿病者相比，糖尿病与认知功能障碍相关（RRR=1.83，95%CI =1.48-2.26）。BMI与认知障碍无关。关于死亡率，糖尿病与风险增加相关（RRR=2.28，95%CI =1.98-2.63），超重或肥胖与风险降低相关（RRR=0.74，95%CI =0.65-0.86; RRR=0.79，95%CI = 0.66-0.95）。当BMI和糖尿病合并时，与BMI正常但无糖尿病的患者相比，仅患有糖尿病（RRR=2.01，95% CI=1.40-2.87）、超重伴糖尿病（RRR=1.42，95% CI=1.02-1.97）或患有糖尿病肥胖（RRR= 1.70，95% CI=1.16，2.48）与认知障碍相关。无论BMI如何，糖尿病都与死亡风险增加有关，而超重或肥胖与死亡风险降低有关。随着墨西哥人肥胖和糖尿病患病率的增加，重要的是要了解这些疾病及其并发症如何影响认知障碍和死亡率。在老年墨西哥人中，糖尿病与6年死亡率和认知障碍发作有关，可能是由糖尿病的影响驱动的。
Diabetes is a risk factor for dementia and mortality, while obesity later in life is associated with a reduced risk. Their co-occurrence, diabesity, is common, but its association with dementia and mortality is unclear. Using data from the Mexican Health and Aging Study, we used multinomial logistic regression to examine the associations of diabetes and body mass index (BMI), and diabesity, in 2012, with cognitive impairment and mortality in 2018, among participants aged ≥60 years with normal cognition at baseline (n=7,885). Diabetes was associated with cognitive impairment, compared to not having diabetes (RRR=1.83, 95% CI=1.48-2.26). BMI was not associated with cognitive impairment. Regarding mortality, diabetes was associated with an increased risk (RRR=2.28, 95% CI=1.98-2.63) and being overweight or having obesity was associated with a reduced risk (RRR=0.74, 95% CI=0.65-0.86; RRR=0.79, 95% CI= 0.66-0.95). When BMI and diabetes were combined, having diabetes only (RRR=2.01, 95% CI=1.40-2.87), being overweight with diabetes (RRR=1.42, 95% CI=1.02-1.97) or having diabesity (RRR= 1.70, 95% CI=1.16, 2.48) were associated with cognitive impairment, compared to having a normal BMI without diabetes. Diabetes, regardless of BMI, was associated with an increased risk of mortality, while being overweight or having obesity was associated with a reduced risk of mortality. With the increase in the prevalence of obesity and diabetes among Mexicans, it is important to understand how these conditions and their co-occurrence impact cognitive impairment and mortality. Among older Mexicans, diabesity is associated with 6-year mortality and cognitive impairment onset, likely driven by the effect of diabetes.
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DOI：
10.1016/j.dadm.2017.05.007
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Albanese E;Launer LJ;Egger M;Prince MJ;Giannakopoulos P;Wolters FJ;Egan K
通讯作者：
Egan K
影响因子：
2.1
作者：
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通讯作者：
Neuhaus, John
影响因子：
6.9
作者：
JORM, AF
通讯作者：
JORM, AF
影响因子：
2.8
作者：
Mejia-Arango, Silvia;Miguel Gutierrez, Luis
通讯作者：
Miguel Gutierrez, Luis
影响因子：
7
作者：
Perales, Jaime;Hinton, Ladson;Vidoni, Eric D.
通讯作者：
Vidoni, Eric D.