Pfam: The protein families database in 2021.
Pfam: The protein families database in 2021.
复制标题
DOI：
10.1093/nar/gkaa913
复制
发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Bateman A
中科院分区：
文献类型：
--
作者：
Mistry J;Chuguransky S;Williams L;Qureshi M;Salazar GA;Sonnhammer ELL;Tosatto SCE;Paladin L;Raj S;Richardson LJ;Finn RD;Bateman A
Pfam数据库是用于将蛋白质序列分类为家族和域的广泛使用的资源。自从Pfam最后一次在本期刊中描述以来，Pfam 33.1中增加了350多个新家族，并对现有条目进行了许多改进。为了促进对COVID-19的研究，我们修订了Pfam中涵盖SARS-CoV-2蛋白质组的条目，并为Pfam未涵盖的区域建立了新条目。我们重新引入了Pfam-B，它提供了一个自动生成的补充Pfam，并包含136 730个新的序列簇，尚未匹配的Pfam家族。新的Pfam-B基于MMseqs 2软件的聚类。我们已经将RepeatsDB中的所有区域与Pfam中的区域进行了比较，并开始使用结果来构建和改进Pfam重复序列家族。Pfam可在http://pfam.xfam.org/免费浏览和下载。
The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries. To facilitate research on COVID-19, we have revised the Pfam entries that cover the SARS-CoV-2 proteome, and built new entries for regions that were not covered by Pfam. We have reintroduced Pfam-B which provides an automatically generated supplement to Pfam and contains 136 730 novel clusters of sequences that are not yet matched by a Pfam family. The new Pfam-B is based on a clustering by the MMseqs2 software. We have compared all of the regions in the RepeatsDB to those in Pfam and have started to use the results to build and refine Pfam repeat families. Pfam is freely available for browsing and download at http://pfam.xfam.org/.
登录
查看更多内容
Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
通讯作者：
Bateman, Alex
影响因子：
14.9
作者：
Mitchell AL;Attwood TK;Babbitt PC;Blum M;Bork P;Bridge A;Brown SD;Chang HY;El-Gebali S;Fraser MI;Gough J;Haft DR;Huang H;Letunic I;Lopez R;Luciani A;Madeira F;Marchler-Bauer A;Mi H;Natale DA;Necci M;Nuka G;Orengo C;Pandurangan AP;Paysan-Lafosse T;Pesseat S;Potter SC;Qureshi MA;Rawlings ND;Redaschi N;Richardson LJ;Rivoire C;Salazar GA;Sangrador-Vegas A;Sigrist CJA;Sillitoe I;Sutton GG;Thanki N;Thomas PD;Tosatto SCE;Yong SY;Finn RD
通讯作者：
Finn RD
DOI：
10.1016/0097-8485(93)85006-x
发表时间：
1993-06-01
期刊：
COMPUTERS & CHEMISTRY
影响因子：
--
作者：
WOOTTON, JC;FEDERHEN, S
通讯作者：
FEDERHEN, S
影响因子：
3.7
作者：
Kopec KO;Lupas AN
通讯作者：
Lupas AN
影响因子：
14.9
作者：
Paladin, Lisanna;Hirsh, Layla;Tosatto, Silvio C. E.
通讯作者：
Tosatto, Silvio C. E.