Sensory activity differentially modulates N-methyl-D-aspartate receptor subunits 2A and 2B in cortical layers.
Sensory activity differentially modulates N-methyl-D-aspartate receptor subunits 2A and 2B in cortical layers.
复制标题
DOI：
10.1016/j.neuroscience.2009.07.016
复制
发表时间：
2009-10-20
期刊：
影响因子：
3.3
通讯作者：
Erisir, A.
中科院分区：
文献类型：
--
作者：
Corson, J.;Nahmani, M.;Lubarsky, K.;Badr, N.;Wright, C.;Erisir, A.
含有选择性NR2亚基的NMDA受体的活动依赖性调节已经涉及发育和成年感觉皮层的塑性过程。为了揭示NR2亚基对感觉活动持续变化的不同敏感性，我们利用了四种阻断、恢复或启动感觉视觉活动的范式。采用定量电子显微镜对出生后和成年雪貂视皮层中含NR2A和NR2B突触的层状患病率进行了评估。所有年龄段的光剥夺导致NR2A的下调，而从剥夺中恢复导致上调。此外，过早的眼睑打开导致NR2A的过早增加。因此，无论皮层层或年龄如何，黑暗和光明时期之间的转换都快速且双向地调节NR2A。相比之下，NR2B调节是层和年龄依赖性的。只有在第四层，NR2B的患病率显示一个一次性的下降约三个星期后开始的感觉活动后，正常或过早的眼睑开放，或终止后的黑暗饲养。NR2A和NR2B的活动调制模式的不一致性与这些亚基参与两个不同的，但部分共同发生的过程是一致的：发育可塑性的关键时期，和终身的可塑性，这是建立在早期发育年龄。
Activity-dependent modulation of NMDA receptors containing selective NR2 subunits has been implicated in plastic processes in developing and adult sensory cortex. Aiming to reveal differential sensitivity of NR2 subunits to sustained changes in sensory activity, we utilized four paradigms that blocked, reinstated, or initiated sensory visual activity. Laminar prevalence of NR2A- and NR2B-containing synapses in visual cortex of postnatal and adult ferrets was assessed using quantitative electron microscopy. Light-deprivation at all ages resulted in a downregulation of NR2A, while recovery from deprivation resulted in an upregulation. Furthermore, premature eyelid opening caused a precocious increase of NR2A. Thus, transitions between periods of dark and light rapidly and bidirectionally regulate NR2A, regardless of cortical layer or age. In contrast, NR2B regulation is layer- and age-dependent. Only in layer IV, NR2B prevalence displays a one-time decline about three weeks after the initiation of sensory activity upon normal or premature eyelid opening, or upon termination of dark-rearing. Incongruity in patterns of NR2A and NR2B modulation by activity is consistent with involvement of these subunits in two distinct, yet partially co-occurring processes: developmental plasticity with a critical period, and life-long plasticity that is established in early developmental ages.
登录
查看更多内容
影响因子：
1.8
作者：
Daw, N;Yan, R;Yang, YP
通讯作者：
Yang, YP
影响因子：
5.3
作者：
Corlew, Rebekah;Wang, Yun;Philpot, Benjamin D.
通讯作者：
Philpot, Benjamin D.
影响因子：
5.3
作者：
CRAGG, BG
通讯作者：
CRAGG, BG
DOI：
10.1073/pnas.0609596104
发表时间：
2007-01-23
影响因子：
11.1
作者：
Crozier, Robert A.;Wang, Yun;Bear, Mark F.
通讯作者：
Bear, Mark F.
DOI：
10.1098/rstb.2002.1255
发表时间：
2003-04-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Bear, MF
通讯作者：
Bear, MF