Advanced glycation end products and diabetic complications.
Advanced glycation end products and diabetic complications.
复制标题
DOI：
10.4196/kjpp.2014.18.1.1
复制
发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Jaggi AS
中科院分区：
文献类型：
--
作者：
Singh VP;Bali A;Singh N;Jaggi AS
在糖尿病的长期高血糖状态期间，葡萄糖通过称为糖化的非酶促过程与血浆蛋白形成共价加合物。蛋白质糖基化和糖基化终产物（AGEs）的形成在糖尿病并发症如视网膜病变、肾病、神经病变、心肌病沿着以及其他疾病如类风湿性关节炎、骨质疏松症和衰老的发病机制中起重要作用。蛋白质的糖基化通过破坏分子构象、改变酶活性和干扰受体功能来干扰其正常功能。AGEs不仅与蛋白质形成细胞内和细胞外交联，而且与一些其他内源性关键分子（包括脂质和核酸）形成细胞内和细胞外交联，从而促进糖尿病并发症的发展。最近的研究表明，AGEs与质膜定位的AGEs受体（AGEs）相互作用，改变细胞内信号传导，基因表达，促炎分子和自由基的释放。本文综述了血浆蛋白如白蛋白、纤维蛋白原、球蛋白和胶原的糖基化形成不同类型的AGEs。此外，AGEs在糖尿病并发症包括视网膜病变，白内障，神经病变，肾病和心肌病的发病机制中的作用也进行了讨论。
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with their normal functions by disrupting molecular conformation, altering enzymatic activity, and interfering with receptor functioning. AGEs form intra- and extracellular cross linking not only with proteins, but with some other endogenous key molecules including lipids and nucleic acids to contribute in the development of diabetic complications. Recent studies suggest that AGEs interact with plasma membrane localized receptors for AGEs (RAGE) to alter intracellular signaling, gene expression, release of pro-inflammatory molecules and free radicals. The present review discusses the glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs. Furthermore, the role of AGEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is also discussed.
登录
查看更多内容
比较人血清白蛋白在不同糖化阶段形成的修饰位点。
DOI：
10.1016/j.cca.2010.10.018
发表时间：
2011-01-30
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Barnaby OS;Cerny RL;Clarke W;Hage DS
通讯作者：
Hage DS
影响因子：
3.4
作者：
Ai J;Liu Y;Sun JH
通讯作者：
Sun JH
影响因子：
8.2
作者：
Berner, A. K.;Brouwers, O.;Stitt, A. W.
通讯作者：
Stitt, A. W.
影响因子：
4.1
作者：
Alikhani, Mani;Alikhani, Zoubin;Graves, Dana T.
通讯作者：
Graves, Dana T.
DOI：
10.1111/j.1749-6632.2002.tb02107.x
发表时间：
2002-01-01
期刊：
INCREASING HEALTHY LIFE SPAN: CONVENTIONAL MEASURES AND SLOWING THE INNATE AGING PROCESS
影响因子：
--
作者：
Baynes, JW
通讯作者：
Baynes, JW