Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.
Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.
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DOI：
10.1371/journal.pone.0281949
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然有许多关于亚洲移民到西方和炎症性肠病（IBD）风险的流行病学研究，但亚洲IBD患者（特别是儿童）的表型和生活方式并没有得到很好的描述。在这项研究中，我们描述了生活方式的做法，如饮食模式，以及疾病表型在亚裔美国儿童IBD。我们回顾了患有IBD的儿童的记录，年龄为0至21岁，种族确定为亚洲人，印度人或太平洋岛民。纳入了2013年1月至2020年1月期间在我们中心接受IBD门诊治疗的患者。我们排除了国际第二意见的患者，这些患者没有明确的IBD诊断，并且在18岁之后诊断出IBD。在该队列中设计并进行了一项调查，包括根据NHANES DSQ改编的食物频率问卷，并进行了修改，以纳入文化上适当的食物元素，以评估饮食模式。我们队列中的亚洲患者与非亚洲患者具有相似的表型，几乎没有显著差异。克罗恩病和男性优势与非亚洲人相似。然而，在亚洲患者中，溃疡性结肠炎中直肠炎的发生率很高。亚洲患者报告了一种典型的饮食模式，反映了西化的模式，而不是传统的模式。尽管饮食模式相似，但25-OH维生素D缺乏（44%）和不足（40%）的比例很高。这项单中心研究表明，在美国患有IBD的亚洲儿童的表型与非亚洲儿童的表型相似，但有一些明显的差异。我们队列中的亚洲儿童报告遵循西方化的饮食模式和生活方式。然而，有一个高比例的维生素D缺乏症周围的诊断，这表明需要警惕的监测。
While there are many epidemiologic studies of Asian immigrants to the West and risk of inflammatory bowel disease (IBD), the phenotype and lifestyle of Asian patients, particularly children, with IBD are not well described. In this study, we describe lifestyle practices, such as dietary pattern, as well as disease phenotype in Asian American children with IBD. We reviewed the records of children with IBD, ages 0 to 21 years old, and race identified as Asian, Indian, or Pacific Islander. Patients who received outpatient IBD care at our center between January 2013 and January 2020 were included. We excluded patients who were international second opinions, who did not have a definitive diagnosis of IBD, and in whom a diagnosis of IBD was made after 18 years of age. A survey, including a food frequency questionnaire adapted from NHANES DSQ with modifications to include culturally appropriate food elements, was designed and conducted within this cohort to assess for dietary patterns. Asian patients in our cohort have similar phenotypes as non-Asians with few distinctive differences. There was a Crohn’s disease and male predominance similar with non-Asians. However, there was a high rate of proctitis in ulcerative colitis in Asian patients. Asian patients reported a typical dietary pattern that reflects a Westernized pattern rather than a traditional pattern. Despite a similar dietary pattern, there was a high rate of 25-OH Vitamin D deficiency (44%) and insufficiency (40%). This single center study showed that the phenotype of Asian children with IBD in the U.S. is similar with that of non-Asian with a few distinct differences. The Asian children in our cohort reported following a Westernized dietary pattern and lifestyle. However, there was a high rate of Vitamin D deficiency surrounding diagnosis, suggesting a need for vigilant monitoring.
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