Titan cells in Cryptococcus neoformans: cells with a giant impact.
Titan cells in Cryptococcus neoformans: cells with a giant impact.
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DOI：
10.1016/j.mib.2013.03.006
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发表时间：
2013-08
影响因子：
5.4
通讯作者：
Nielsen K
中科院分区：
文献类型：
--
作者：
Zaragoza O;Nielsen K
新型隐球菌是一种致病性酵母菌，通常感染免疫功能低下的个体，但已发展出多种适应宿主的机制。几种毒力因子（荚膜和黑色素）已被发现多年。然而，这种酵母也具有一个形态发生程序，仍然没有很好的特点。新型隐球菌在感染过程中具有显著扩大其尺寸的能力，以形成细胞体直径可达100微米的“泰坦细胞”，而典型尺寸的细胞为5-7微米。这些泰坦细胞给宿主带来了一个问题，因为它们有助于真菌的生存，传播到中枢神经系统，甚至可能潜伏。在这篇综述中，我们将提供这些细胞的概述，涵盖目前的知识，其表型特征，形成机制，以及它们在感染过程中的意义。
Cryptococcus neoformans is a pathogenic yeast that commonly infects immunocompromised individuals, yet has developed multiple adaptation mechanisms to the host. Several virulence factors (capsule and melanin) have been known for many years. However, this yeast also possesses a morphogenetic program that is still not well characterized. Cryptococcus neoformans has the ability to dramatically enlarge its size during infection to form “titan cells” that can reach up to 100 microns in cell body diameter, in contrast to typical size cells of 5-7 microns. These titan cells pose a problem for the host because they contribute to fungal survival, dissemination to the central nervous system, and possibly even latency. In this review, we will provide an overview of these cells, covering current knowledge about their phenotypic features, mechanism of formation, and their significance during infection.
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影响因子：
--
作者：
Okagaki, Laura H.;Wang, Yina;Nielsen, Kirsten
通讯作者：
Nielsen, Kirsten
影响因子：
6.7
作者：
O'Meara TR;Norton D;Price MS;Hay C;Clements MF;Nichols CB;Alspaugh JA
通讯作者：
Alspaugh JA
影响因子：
--
作者：
Zaragoza, Oscar;Rodrigues, Marcio L.;De Jesus, Magdia;Frases, Susana;Dadachova, Ekaterina;Casadevall, Arturo
通讯作者：
Casadevall, Arturo
DOI：
10.1038/nrmicro2522
发表时间：
2011-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Kronstad JW;Attarian R;Cadieux B;Choi J;D'Souza CA;Griffiths EJ;Geddes JM;Hu G;Jung WH;Kretschmer M;Saikia S;Wang J
通讯作者：
Wang J
影响因子：
6.7
作者：
Okagaki LH;Strain AK;Nielsen JN;Charlier C;Baltes NJ;Chrétien F;Heitman J;Dromer F;Nielsen K
通讯作者：
Nielsen K