Impaired T Cell-dependent Humoral Immune Response Associated with Juvenile-onset Recurrent Respiratory Papillomatosis Progression.
Impaired T Cell-dependent Humoral Immune Response Associated with Juvenile-onset Recurrent Respiratory Papillomatosis Progression.
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T 细胞依赖性体液免疫反应受损与青少年发病的复发性呼吸道乳头状瘤病进展相关
DOI：
10.1038/srep36378
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发表时间：
2016-11-08
影响因子：
4.6
通讯作者：
Ni X
中科院分区：
文献类型：
--
作者：
Wu X;Wang G;Chen X;Zhang J;Zhao J;Wang J;Xiao Y;Tai J;Wang S;Wang G;Wang H;Bai L;Gui J;Ni X
体液免疫是否在HPV 6型或11型病毒介导的青少年复发性呼吸道乳头状瘤病（JORRP）中起作用仍不清楚。44例JORRP患者血清总IgG水平显著低于40例健康对照者。此外，在JORRP患者的外周血中发现了扩增的CD 3 − CD 19 +B细胞，其CD 23、CD 40、HLA-DR表达下调，CD 86表达上调。流式细胞仪分析显示，JORRP患者外周血中CD 19 + CD 27 + hipplasma细胞和CD 19 + CD 27+记忆B细胞的比例均降低。重要的是，尽管循环CXCR 5 + PD 1 hiTfh细胞的比例没有改变，但Tfh细胞的功能大大受损，IL-21分泌促进B细胞成熟的能力降低。Kaplan-Meier法相关分析显示，分泌IL-21的Tfh细胞与JORRP患者CD 27 +B细胞亚群频率、血清IgG水平和复发频率呈正相关，而与IgD+ CD 27 −B细胞百分比呈负相关。我们的结论是，Tfh细胞分泌的IL-21减少可能限制了JORRP患者的B细胞成熟和抗体产生，并且Tfh细胞来源的IL-21可能与JORRP的临床结局相关。
Whether humoral immunity plays a role in HPV type 6 or 11 virus-mediated Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP) remains unknown. In the present study, serum total IgG level in 44 JORRP patients was significantly decreased compared with that in 40 healthy controls. Moreover, expanded CD3−CD19+B cells with down-regulation of CD23, CD40, HLA-DR and up-regulation of CD86 expression were found in the peripheral blood of JORRP patients. Flow cytometry analysis of B-cell compartment showed that the frequency of both CD19+CD27hiplasma cells and CD19+CD27+memory B cells were decreased in JORRP patients. Importantly, although the proportion of circulating CXCR5+PD1hiTfh cells was not changed, the function of Tfh cells were greatly impaired with reduced ability of IL-21 secretion to promote B cell maturation. Association analysis by the Kaplan-Meier method revealed that IL-21 secreting Tfh cell was positively correlated to the CD27+B cell subset frequency, the serum IgG level and the frequency of recurrence in JORRP patients, but negatively correlated to the percentage of IgD+CD27−B cell. We concluded that a reduced IL-21 secretion by Tfh cells may limit B cell maturation and antibody production in JORRP patients and Tfh cell-derived IL-21 might be associated with JORRP outcome in clinic.
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影响因子：
16.8
作者：
Schmidlin H;Diehl SA;Blom B
通讯作者：
Blom B
影响因子：
32.4
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
通讯作者：
Dong, Chen
影响因子：
15.9
作者：
Gu-Trantien, Chunyan;Loi, Sherene;Willard-Gallo, Karen
通讯作者：
Willard-Gallo, Karen
影响因子：
2.2
作者：
Deneys, V;Mazzon, AM;De Bruyère, M
通讯作者：
De Bruyère, M
影响因子：
3.7
作者：
Huo Z;Bissett SL;Giemza R;Beddows S;Oeser C;Lewis DJ
通讯作者：
Lewis DJ