Towards reliable spike-train recordings from thousands of neurons with multielectrodes.

Towards reliable spike-train recordings from thousands of neurons with multielectrodes.
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DOI:
10.1016/j.conb.2011.10.001
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发表时间:
2012-02
影响因子:
5.7
通讯作者:
Harris KD
Harris KD
中科院分区:
医学2区
文献类型:
--
作者:
Einevoll GT;Franke F;Hagen E;Pouzat C;Harris KD

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新一代硅基多电极包括数百个或更多的电极触点,为同时记录数千个神经元的尖峰序列提供了前所未有的可能性。这些数据不仅对于发现大脑中的神经网络如何工作非常宝贵,而且对于神经假体应用也很重要。只有提供有效、准确和经过验证的自动穗分选方法,才能实现这一机会。在这篇评论中,我们描述了一些必须满足的挑战,以实现这一目标,特别是认为现实的模型数据被用作地面真理的尖峰排序算法的验证的关键需求。
The new generation of silicon-based multielectrodes comprising hundreds or more electrode contacts offers unprecedented possibilities for simultaneous recordings of spike trains from thousands of neurons. Such data will not only be invaluable for finding out how neural networks in the brain work, but will likely be important also for neural prosthesis applications. This opportunity can only be realized if efficient, accurate and validated methods for automatic spike sorting are provided. In this review we describe some of the challenges that must be met to achieve this goal, and in particular argue for the critical need of realistic model data to be used as ground truth in the validation of spike-sorting algorithms.
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