The effects of continuous 5-HT(3) receptor antagonist administration on the subsequent behavioral response to cocaine.
The effects of continuous 5-HT(3) receptor antagonist administration on the subsequent behavioral response to cocaine.
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连续给予 5-HT(3) 受体拮抗剂对可卡因随后行为反应的影响。
DOI：
10.1016/s0014-2999(02)02036-8
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发表时间：
2002
影响因子：
5
通讯作者：
Hilburn,Craig
中科院分区：
文献类型：
--
作者：
King,GeorgeR;Pinto,Gail;Konen,Jennifer;Castro,Gene;Tran,Sophie;Hilburn,Craig
A functional down-regulation of central serotonin3 (5-HT3) receptors represents a partial mechanism of the tolerance to cocaine induced by the continuous administration of cocaine. Blocking this down-regulation by co-administering continuous cocaine and daily injections of 5-HT3receptor antagonists blocks the development of tolerance. The present experiment evaluated the ability of continuously administered 5-HT3receptor antagonists, to induce sensitization (reverse tolerance) to the behavioral effects of cocaine, based on the hypothesis that chronic blockade of 5-HT3receptors should induce an up-regulation of these receptors. In all experiments, rats received a 14 day pretreatment involving the continuous administration of tropisetron (0.0, 1.0, 4.0, or 8.0 mg/kg/day) or LY 278,584 (0.001, 0.01, or 0.1 mg/kg/day). The rats were withdrawn for 7 days from this pretreatment regimen. On day 7 of withdrawal from the pretreatment regiment, the rats received a 0.0, 7.5, or 15.0 mg/kg i.p. cocaine challenge. Ambulatory behavior was automatically recorded for 60 min. Both continuous tropisetron and LY 278,584, opposite to the initial hypothesis, induced tolerance, and not sensitization, to the behavioral effects of cocaine. The results clearly indicate that central 5-HT3receptors are critical for the effects of chronic cocaine administration.
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影响因子：
3.6
作者：
M. Reith;H. Sershen;D. Allen;A. Lajtha
通讯作者：
A. Lajtha
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影响因子：
2.3
作者：
Jianping Chen;W. Paredes;H. M. van Praag;J. Lowinson;E. Gardner
通讯作者：
E. Gardner
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DOI：
--
发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Blandina,P;Goldfarb,J;Craddock-Royal,B;Green,JP
通讯作者：
Green,JP
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影响因子：
5
作者：
Blandina,P;Goldfarb,J;Green,JP
通讯作者：
Green,JP
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DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Reith,ME;Benuck,M;Lajtha,A
通讯作者：
Lajtha,A