A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus.
A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus.
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一种设计的具有潜在抗耐甲氧西林金黄色葡萄球菌能力的抗菌肽。
DOI：
10.3389/fmicb.2022.1029366
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发表时间：
2022
影响因子：
5.2
通讯作者：
Duan, Zilei
中科院分区：
文献类型：
--
作者：
Yuan, Bingqian;Lu, Xiaoyu;Yang, Min;He, Qiyi;Cha, Zhuocen;Fang, Yaqun;Yang, Yan;Xu, Lei;Yan, Jingting;Lai, Ren;Wang, Aili;Yu, Xiaodong;Duan, Zilei
金黄色葡萄球菌(S.金黄色葡萄球菌）是一种革兰氏阳性病原菌，其在大约20-30%的健康成人群体的前鼻孔中持续地定殖，并且高达60%是间歇性定殖的。随着抗生素的滥用和过度使用，大规模的耐药菌，包括耐甲氧西林S。金黄色葡萄球菌（MRSA）。MRSA是引起社区相关感染的最流行的病原体之一。一旦失控，到2050年，每年因抗菌药物耐药性导致的死亡人数可能超过1000万。抗菌肽（Antimicrobial peptide，AMP）因不易产生耐药性而被认为是最好的解决方案。在前期研究的基础上，本研究设计了一个新的抗菌肽GW 18，该抗菌肽对S.金黄色葡萄球菌，甚至是MRSA，溶血率小于5%，无细胞毒性，无急性毒性。值得注意的是，GW 18的施用显著降低了S.金黄色葡萄球菌感染小鼠模型。这些结果表明GW 18是抗S.金黄色葡萄球菌感染。
Staphylococcus aureus (S. aureus) is a Gram-positive pathogenic bacterium, which persistently colonizes the anterior nares of approximately 20–30% of the healthy adult population, and up to 60% is intermittently colonized. With the misuse and overuse of antibiotics, large-scale drug-resistant bacteria, including methicillin-resistant S. aureus (MRSA), have been appeared. MRSA is among the most prevalent pathogens causing community-associated infections. Once out of control, the number of deaths caused by antimicrobial resistance may exceed 10 million annually by 2050. Antimicrobial peptides (AMPs) are regarded as the best solution, for they are not easy to develop drug resistance. Based on our previous research, here we designed a new antimicrobial peptide named GW18, which showed excellent antimicrobial activity against S. aureus, even MRSA, with the hemolysis less than 5%, no cytotoxicity, and no acute toxicity. Notably, administration of GW18 significantly decreased S. aureus infection in mouse model. These findings identify GW18 as the ideal candidate against S. aureus infection.
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影响因子：
16.6
作者：
Pircher J;Czermak T;Ehrlich A;Eberle C;Gaitzsch E;Margraf A;Grommes J;Saha P;Titova A;Ishikawa-Ankerhold H;Stark K;Petzold T;Stocker T;Weckbach LT;Novotny J;Sperandio M;Nieswandt B;Smith A;Mannell H;Walzog B;Horst D;Soehnlein O;Massberg S;Schulz C
通讯作者：
Schulz C
DOI：
10.1007/s00018-022-04309-y
发表时间：
2022-05-21
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/s2666-5247(21)00327-x
发表时间：
2022-04
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Kanellakis NI;Wrightson JM;Gerry S;Ilott N;Corcoran JP;Bedawi EO;Asciak R;Nezhentsev A;Sundaralingam A;Hallifax RJ;Economides GM;Bland LR;Daly E;Yao X;Maskell NA;Miller RF;Crook DW;Hinks TSC;Dong T;Psallidas I;Rahman NM
通讯作者：
Rahman NM
影响因子：
1.8
作者：
Fukumoto, K;Nagaoka, I;Miyano, T
通讯作者：
Miyano, T
影响因子：
9.7
作者：
Li, Fupeng;Huang, Kai;Liu, Fengxiang
通讯作者：
Liu, Fengxiang