Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons.
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons.
复制标题
通过中间神经元的强直抑制和兴奋来控制海马伽玛振荡频率。
DOI：
10.1038/nn.2464
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发表时间：
2010-02
影响因子：
25
通讯作者：
Mody I
中科院分区：
文献类型：
--
作者：
Mann EO;Mody I
伽马频率振荡依赖于GABAA受体介导的时相突触抑制来同步峰电位计时。突触释放的GABA的溢出也可以激活突触外的GABAA受体，这种紧张性抑制也可能有助于调节网络动力学。在许多类型的神经细胞中，紧张性抑制是由含有δ亚单位的GABA受体介导的。我们发现，通过激活中间神经元上的NMDA受体(NMDAR)，体外胆碱诱导的小鼠海马CA3区伽马振荡的频率增加。含δ亚单位的GABA受体对中间神经元的紧张性抑制可抵消依赖NMDAR的伽马振荡频率的增加。伽马活动期间突触电流的记录表明，NMDAR介导的振荡频率的增加与网络中相性兴奋和抑制的逐渐同步有关。因此，中间神经元的紧张性兴奋和紧张性抑制之间的平衡可能通过形成神经元间同步性来调节伽马频率。
Gamma-frequency oscillations depend on phasic synaptic GABAA receptor-mediated inhibition to synchronize spike timing. The spillover of synaptically-released GABA can also activate extrasynaptic GABAA receptors, and such tonic inhibition may also contribute to modulating network dynamics. In many neuronal cell types, tonic inhibition is mediated by δ subunit-containing GABAA receptors. We show that the frequency of in vitro cholinergically-induced gamma oscillations in the mouse hippocampal CA3 region is increased by the activation of NMDA receptors (NMDAR) on interneurons. The NMDAR-dependent increase of gamma oscillation frequency is counteracted by the tonic inhibition of the interneurons mediated by δ subunit-containing GABAA receptors. Recordings of synaptic currents during gamma activity show that NMDAR-mediated increases in oscillation frequency correlate with a progressive synchronization of phasic excitation and inhibition in the network. Thus, the balance between tonic excitation and tonic inhibition of interneurons may modulate gamma frequency by shaping interneuronal synchronization.
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影响因子：
16.2
作者：
Hormuzdi, SG;Pais, I;Monyer, H
通讯作者：
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