Behavioral and monoamine changes following severe vitamin C deficiency.
Behavioral and monoamine changes following severe vitamin C deficiency.
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严重的维生素C缺乏后，行为和单胺变化。
DOI：
10.1111/jnc.12069
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发表时间：
2013-02
影响因子：
4.7
通讯作者：
Harrison FE
中科院分区：
文献类型：
--
作者：
Ward MS;Lamb J;May JM;Harrison FE
严重维生素C缺乏症（抗坏血酸；AA）在不能合成自身AA的gulo - / -小鼠中引起。在剥夺期之前和期间研究了许多行为测量，包括一个坏血病期，在此期间观察到小鼠体重减轻。然后用AA补充剂使小鼠复苏。在坏血病期间，gulo - / -小鼠表现出自主运动活动减少，体力下降和对高度可口的蔗糖奖励的偏好增加。这些行为在复苏后都恢复到控制水平。在aa剥夺小鼠的社会支配地位的试管试验中，改变的试验时间在复苏后持续存在，这可能表明这些小鼠有类似抑郁的行为。在第二次剥夺期后进行生化分析。AA缺乏伴随着血糖水平下降，皮质脂质和蛋白质氧化损伤，皮质和纹状体中多巴胺和血清素代谢物减少。考虑到饮食中AA摄入量不足的人群比例相当高，这些数据对普通人群的生理和心理功能具有重要意义。
Severe vitamin C deficiency (ascorbic acid; AA) was induced in gulo−/− mice incapable of synthesizing their own AA. A number of behavioral measures were studied before and during the deprivation period, including a scorbutic period, during which weight loss was observed in the mice. Mice were then resuscitated with AA supplements. During the scorbutic period gulo−/−mice showed decreased voluntary locomotor activity, diminished physical strength and increased preference for a highly palatable sucrose reward. These behaviors all returned to control levels following resuscitation. Altered trial times in subordinate mice in the tube test for social dominance in the AA-deprived mice persisted following resuscitation and may signify a depressive-like behavior in these mice. Biochemical analyses were undertaken following a second deprivation period. AA deficiency was accompanied by decreased blood glucose levels, oxidative damage to lipids and proteins in the cortex, and decreases in dopamine and serotonin metabolites in both the cortex and striatum. Given the reasonably high proportions of the population that do not consume sufficient AA in the diet, these data have important implications for physical and psychological function in the general population.
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影响因子：
2.9
作者：
Harrison, Fiona E.;Meredith, M. Elizabeth;Dawes, Sean M.;Saskowski, Jeanette L.;May, James M.
通讯作者：
May, James M.
影响因子：
3.6
作者：
Harrison, F. E.;May, J. M.;McDonald, M. P.
通讯作者：
McDonald, M. P.
影响因子：
7.4
作者：
Harrison FE;May JM
通讯作者：
May JM
DOI：
10.1111/j.1601-183x.2011.00762.x
发表时间：
2012-04
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Chen Y;Curran CP;Nebert DW;Patel KV;Williams MT;Vorhees CV
通讯作者：
Vorhees CV
影响因子：
4.8
作者：
Bornstein, SR;Yoshida-Hiroi, M;Eisenhofer, G
通讯作者：
Eisenhofer, G