Regulation of mTORC1 by the Rag GTPases.
Regulation of mTORC1 by the Rag GTPases.
复制标题
DOI：
10.1042/bst20210038
复制
发表时间：
2023-04-26
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neurodegeneration. The Rag GTPases sense amino acid levels and form heterodimers, where RagA or RagB binds to RagC or RagD, to recruit mTORC1 to the lysosome where it becomes activated. Here, we review amino acid signaling to mTORC1 through the Rag GTPases.
DOI：
10.1016/j.jbc.2021.101103
发表时间：
2021-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fingar DC
通讯作者：
Fingar DC