Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development.
Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development.
复制标题
DOI：
10.1038/cdd.2014.148
复制
发表时间：
2015-02
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖时白色脂肪组织(WAT)的过度生长是脂肪细胞肥大和增殖的结果。脂肪细胞的扩增和更新依赖于白色脂肪细胞前体细胞(WAP)的增殖和分化；然而，WAP对肥胖发生的要求尚未得到证实。在这里，我们调查WAP耗尽是否可以用来防止WAT扩展。我们通过使用一种猎人杀手多肽来测试这一方法，该多肽旨在选择性地诱导WAP中的细胞凋亡。我们发现，在小鼠饮食诱导的肥胖模型中，尽管热量摄入增加，但有针对性的WAP细胞消融导致WAT生长长期受到抑制。我们的数据表明，WAP耗竭导致代偿性脂肪组织数量增加，形成米色脂肪细胞。与已报道的米色脂肪组织的生热能力一致，WAP耗尽的小鼠表现出更多的能量消耗。我们的结论是，靶向白色脂肪细胞前体细胞可以作为持续调节Wat代谢活动的策略。
Overgrowth of white adipose tissue (WAT) in obesity occurs as a result of adipocyte hypertrophy and hyperplasia. Expansion and renewal of adipocytes relies on proliferation and differentiation of white adipocyte progenitors (WAP); however, the requirement of WAP for obesity development has not been proven. Here, we investigate whether depletion of WAP can be used to prevent WAT expansion. We test this approach by using a hunter-killer peptide designed to induce apoptosis selectively in WAP. We show that targeted WAP cytoablation results in a long-term WAT growth suppression despite increased caloric intake in a mouse diet-induced obesity model. Our data indicate that WAP depletion results in a compensatory population of adipose tissue with beige adipocytes. Consistent with reported thermogenic capacity of beige adipose tissue, WAP-depleted mice display increased energy expenditure. We conclude that targeting of white adipocyte progenitors could be developed as a strategy to sustained modulation of WAT metabolic activity.
登录
查看更多内容
影响因子：
23.9
作者：
Caplan AI;Correa D
通讯作者：
Correa D
影响因子：
17.1
作者：
Barnhart KF;Christianson DR;Hanley PW;Driessen WH;Bernacky BJ;Baze WB;Wen S;Tian M;Ma J;Kolonin MG;Saha PK;Do KA;Hulvat JF;Gelovani JG;Chan L;Arap W;Pasqualini R
通讯作者：
Pasqualini R
影响因子：
82.9
作者：
Kolonin, MG;Saha, PK;Arap, W
通讯作者：
Arap, W
影响因子：
64.5
作者：
Cohen P;Levy JD;Zhang Y;Frontini A;Kolodin DP;Svensson KJ;Lo JC;Zeng X;Ye L;Khandekar MJ;Wu J;Gunawardana SC;Banks AS;Camporez JP;Jurczak MJ;Kajimura S;Piston DW;Mathis D;Cinti S;Shulman GI;Seale P;Spiegelman BM
通讯作者：
Spiegelman BM
影响因子：
82.9
作者：
Arap, W;Kolonin, MG;Pasqualini, R
通讯作者：
Pasqualini, R