A Quantitative Digital Subtraction Angiography Technique for Characterizing Reduction in Hepatic Arterial Blood Flow During Transarterial Embolization.
A Quantitative Digital Subtraction Angiography Technique for Characterizing Reduction in Hepatic Arterial Blood Flow During Transarterial Embolization.
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定量数字减影血管造影技术，用于表征经动脉栓塞期间肝动脉血流量的减少。
DOI：
10.1007/s00270-020-02640-0
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发表时间：
2021-03
影响因子：
2.9
通讯作者：
Laeseke PF
中科院分区：
文献类型：
--
作者：
Periyasamy S;Hoffman CA;Longhurst C;Schefelker GC;Ozkan OS;Speidel MA;Laeseke PF
There is no standardized and objective method for determining the optimal treatment endpoint (sub-stasis) during transarterial embolization. The objective of this study was to demonstrate the feasibility of using a quantitative digital subtraction angiography (qDSA) technique to characterize intra-procedural changes in hepatic arterial blood flow velocity in response to transarterial embolization in an in vivo porcine model. Eight domestic swine underwent bland transarterial embolizations to partial and sub-stasis angiographic endpoints with intraprocedural DSA acquisitions. Embolized lobes were assessed on histopathology for ischemic damage and tissue embolic particle density. Analysis of target vessels used qDSA and a commercially available color-coded DSA (ccDSA) tool to calculate blood flow velocities and time-to-peaks respectively. Blood flow velocities calculated using qDSA showed a statistically significant difference (p<0.01) between partial- and sub-stasis endpoints whereas time-to-peaks calculated using ccDSA did not show a significant difference. During the course of embolizations, the average correlation with volume of particles delivered was larger for qDSA (-0.86) than ccDSA (0.36). There was a statistically smaller mean-squared error (p<0.01) and larger coefficient of determination (p<0.01) for qDSA compared to ccDSA. On pathology, the degree of embolization as calculated by qDSA had a moderate, positive correlation (p<0.01) with the tissue embolic particle density of ischemic regions within the embolized lobe. qDSA was able to quantitatively discriminate angiographic embolization endpoints and, compared to a commercially available ccDSA method, improve intra-procedural characterization of blood flow changes. Additionally, the qDSA endpoints correlated with tissue-level changes.
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影响因子：
19.7
作者：
Larson, Andrew C.;Wang, Dingxin;Omary, Reed A.
通讯作者：
Omary, Reed A.
DOI：
10.1016/j.ijrobp.2009.06.069
发表时间：
2010-02-01
影响因子：
7
作者：
Kennedy, Andrew S.;Kleinstreuer, Clement;Dezarn, William A.
通讯作者：
Dezarn, William A.
影响因子：
--
作者：
Ghibes, Patrick;Hefferman, Gerald;Groezinger, Gerd
通讯作者：
Groezinger, Gerd
DOI：
10.1016/j.jvir.2018.04.012
发表时间：
2018-10-01
影响因子：
2.9
作者：
Lin, Ethan Yiyang;Lee, Rheun-Chuan;Kowarschik, Markus
通讯作者：
Kowarschik, Markus
DOI：
10.2214/ajr.10.4770
发表时间：
2011-04
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Jin B;Wang D;Lewandowski RJ;Riaz A;Ryu RK;Sato KT;Larson AC;Salem R;Omary RA
通讯作者：
Omary RA