It's Morphin' time: how multiple signals converge on ARF transcription factors to direct development.
It's Morphin' time: how multiple signals converge on ARF transcription factors to direct development.
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DOI：
10.1016/j.pbi.2020.04.008
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发表时间：
2020-10
影响因子：
9.5
通讯作者：
Nemhauser JL
中科院分区：
文献类型：
--
作者：
Lanctot A;Nemhauser JL
植物的发展计划是不断更新的信息，包括环境条件，目前可用的资源和活跃的器官发生的地点。这些信息大多编码在转录因子的修饰中，从而导致其相对丰度、活性和定位的变化。最近对生长素反应因子家族转录因子的研究突出了这种修饰的多样性，以及它们如何协同或拮抗地调节下游反应。arf可以通过选择性剪接、翻译后修饰和亚细胞定位以及许多其他机制来调节。除了多种方式调节arf本身外，它们还可以与其他转录因子合作，使具有不同发育结果的高度复杂的遗传网络成为可能。像arf这样的多层次调控有能力在转录输出中产生灵活性，以及对短期扰动的弹性。
Plant development programs are constantly updated by information about environmental conditions, currently available resources, and sites of active organogenesis. Much of this information is encoded in modifications of transcription factors that lead to changes in their relative abundance, activity and localization. Recent work on the Auxin Response Factor family of transcription factors has highlighted the large diversity of such modifications, as well as how they may work synergistically or antagonistically to regulate downstream responses. ARFs can be regulated by alternative splicing, post-translational modification, and subcellular localization, among many other mechanisms. Beyond the many ways ARFs themselves can be regulated, they can also act cooperatively with other transcription factors to enable highly complex genetic networks with distinct developmental outcomes. Multi-level regulation like what has been documented for ARFs has the capacity to generate flexibility in transcriptional outputs, as well as resilience to short-term perturbations.
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