Plasma Resolvin D2 to Leukotriene B(4) Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis.
Plasma Resolvin D2 to Leukotriene B(4) Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis.
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患有缺血性中风的糖尿病患者血浆 Resolvin D2 与白三烯 B-4 的比率降低且与预后相关
DOI：
10.1155/2021/6657646
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发表时间：
2021
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Miao Z;Tang X;Schultzberg M;Zhao Y;Wang X
糖尿病（DM）会加重急性缺血性脑卒中（AIS）的症状和预后，炎症在其中起重要作用。消退素D2（RvD2）是一种特殊的促消退介质（SPM），而白三烯B4（LTB4）是一种经典的促炎介质。RvD2与LTB4的比值是促消退/促炎平衡的一个指标。我们旨在探讨RvD2/LTB4比值在合并糖尿病的缺血性脑卒中中的作用。
采用酶联免疫吸附测定法分析患有糖尿病的脑卒中患者（DM + AIS组）和无糖尿病的患者（非DM + AIS组）血浆中RvD2和LTB4的水平。在脑卒中发病90天后对患者进行随访，并评估改良Rankin量表评分（mRS）。还分析了RvD2/LTB4比值与脑卒中严重程度和预后的相关性。
血浆中RvD2水平与LTB4呈正相关。DM + AIS组的RvD2/LTB4比值低于非DM + AIS组。未发现RvD2/LTB4比值与梗死面积或美国国立卫生研究院卒中量表（NIHSS）评分之间存在相关性。预后不良组（mRS≥3）基线时的RvD2/LTB4比值显著低于预后良好组（mRS≤2）。
我们的研究表明，在缺血性脑卒中中，糖尿病损害了促消退和促炎介质之间的平衡。RvD2/LTB4比值可作为缺血性脑卒中预后的一个生物标志物。
Diabetes mellitus (DM) aggravates symptoms and prognosis of acute ischemic stroke (AIS), and inflammation plays an important role therein. Resolvin D2 (RvD2) is one of the specialized pro-resolving mediators (SPMs), while leukotriene B4 (LTB4) is a classic proinflammatory mediator. The ratio of RvD2 to LTB4 is an index of pro-resolving/proinflammatory balance. We aim to explore the role of RvD2/LTB4 ratio in ischemic stroke complicated with DM. The plasma levels of RvD2 and LTB4 were analyzed by enzyme immunoassay in stroke patients with DM (DM + AIS group) or without DM (nonDM+AIS group). Patients were followed up at 90 days after stroke onset, and modified Rankin Score (mRS) was assessed. The association of RvD2/LTB4 ratio with stroke severity and prognosis was also analyzed. The plasma levels of RvD2 were positively correlated to LTB4. The RvD2/LTB4 ratio in DM + AIS group was lower than that in the nonDM+AIS group. No correlation was found between the RvD2/LTB4 ratio and infarct size or NIHSS score. The RvD2/LTB4 ratio at baseline was significantly lower in the poor prognosis group (mRS ≥ 3) than that in the good prognosis group (mRS ≤ 2). Our study indicated that the balance between pro-resolving and proinflammatory mediators was impaired by diabetes in ischemic stroke. The RvD2/LTB4 ratio may serve as a biomarker of prognosis for ischemic stroke.
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DOI：
10.4049/jimmunol.1602090
发表时间：
2018-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Sham HP;Walker KH;Abdulnour RE;Krishnamoorthy N;Douda DN;Norris PC;Barkas I;Benito-Figueroa S;Colby JK;Serhan CN;Levy BD
通讯作者：
Levy BD
影响因子：
5.9
作者：
Ramiro L;Simats A;García-Berrocoso T;Montaner J
通讯作者：
Montaner J
影响因子：
3.1
作者：
Herrera, Bruno S.;Hasturk, Hatice;Van Dyke, Thomas E.
通讯作者：
Van Dyke, Thomas E.
影响因子：
16.6
作者：
Fredman, Gabrielle;Hellmann, Jason;Proto, Jonathan D.;Kuriakose, George;Colas, Romain A.;Dorweiler, Bernhard;Connolly, E. Sander;Solomon, Robert;Jones, David M.;Heyer, Eric J.;Spite, Matthew;Tabas, Ira
通讯作者：
Tabas, Ira
影响因子：
3.7
作者：
Shi H;Carion TW;Jiang Y;Chahine A;Steinle JJ;Berger EA
通讯作者：
Berger EA