Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management.
Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management.
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DOI：
10.1177/1756286418789340
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发表时间：
2018
影响因子：
5.9
通讯作者：
Montaner J
中科院分区：
文献类型：
--
作者：
Ramiro L;Simats A;García-Berrocoso T;Montaner J
中风是全球第五大致死原因和最常见的致残原因。目前，中风的诊断是基于神经成像的，因此，缺乏快速诊断中风的工具仍然是一个主要问题。此外，抗击缺血性中风的治疗方法仍然很少，因为唯一被批准的治疗方法是针对恢复受影响脑区的血液流动。然而，由于这些治疗方法的有效时间窗口缩短，很少有患者从中受益；因此，迫切需要替代治疗方法来减少中风脑损伤，以改善患者的预后。脑缺血事件后触发的炎症反应在卒中的进展中起着重要作用，因此，近几十年来，对卒中急性期炎症分子的研究越来越受到人们的关注。在这里，我们概述了在缺血性卒中中发生的炎症过程，以及这些炎症分子成为卒中生物标志物的可能性，以及这些候选分子成为有趣的神经保护性治疗靶点的可能性，以被阻断或刺激，以调节卒中后的炎症。
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide. Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to diagnose stroke is still a major concern. In addition, therapeutic approaches to combat ischemic stroke are still scarce, since the only approved therapies are directed toward restoring blood flow to the affected brain area. However, due to the reduced time window during which these therapies are effective, few patients benefit from them; therefore, alternative treatments are urgently needed to reduce stroke brain damage in order to improve patients’ outcome. The inflammatory response triggered after the ischemic event plays an important role in the progression of stroke; consequently, the study of inflammatory molecules in the acute phase of stroke has attracted increasing interest in recent decades. Here, we provide an overview of the inflammatory processes occurring during ischemic stroke, as well as the potential for these inflammatory molecules to become stroke biomarkers and the possibility that these candidates will become interesting neuroprotective therapeutic targets to be blocked or stimulated in order to modulate inflammation after stroke.
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