Factors predicting health-related quality of life in pediatric liver transplant recipients in the functional outcomes group.
Factors predicting health-related quality of life in pediatric liver transplant recipients in the functional outcomes group.
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DOI：
10.1111/petr.12126
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发表时间：
2013-11
影响因子：
1.3
通讯作者：
Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG)
中科院分区：
文献类型：
--
作者：
Alonso EM;Martz K;Wang D;Yi MS;Neighbors K;Varni JW;Bucuvalas JC;Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG)
来自997名儿童肝移植（LT）受者的数据被用于将人口统计学和医学变量建模为健康相关生活质量（HRQOL）较低水平的预测因子。数据是通过儿童肝移植研究（SPLIT）功能结局小组（FOG）项目收集的。患者年龄在2 - 18岁之间，肝移植后存活至少12个月。父母和儿童（年龄≥8岁）在一个时间点完成了儿童生活质量量表（PedsQL™）4.0通用核心和认知功能量表。人口统计学和医学变量从SPLIT获取。HRQOL分数根据每项测量得分的后25%被归类为“差”。生成了逻辑回归模型。单亲家庭（比值比1.94，置信区间1.13 - 3.33，p = 0.017）、抗癫痫药物（比值比3.99，置信区间1.26 - 12.70，p = 0.019）以及住院天数（比值比1.03，置信区间1.01 - 1.06，p = 0.0067）与自我报告的较低HRQOL相关。父母数据确定移植时年龄较大、调查时年龄在5 - 12岁、肝移植时住院>21天、再次手术、肝移植时患有糖尿病和生长发育不良是通用HRQOL的其他预测因子。男性、单亲家庭、肝移植时胆红素水平较高以及使用抗癫痫药物预测认知功能得分较低。儿童肝移植后的HRQOL与医学和人口统计学变量相关。
Data from 997 pediatric liver transplant (LT) recipients were used to model demographic and medical variables as predictors of lower levels of health related quality of life (HRQOL). Data were collected through Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG) project. Patients were between 2-18 years of age and survived LT by at least 12 months. Parents and children (age ≥ 8 years) completed PedsQL ™ 4.0 Generic Core and Cognitive Functioning Scales at one time point. Demographic and medical variables were obtained from SPLIT. HRQOL scores were categorized “poor” based on lower 25% of scores for each measure. Logistic regression models were generated. Single-parent households (OR 1.94, CI 1.13 – 3.33, p=0.017), anti-seizure medications (OR 3.99, CI 1.26 – 12.70, p=0.019) and number of days hospitalized (OR 1.03, CI 1.01 – 1.06, p=0.0067) were associated with lower self-reported HRQOL. Parent data identified increasing age at transplant, age 5-12 years at survey, hospitalization > 21 days at LT, re-operations, diabetes and growth failure at LT as additional predictors of generic HRQOL. Male gender, single-parent households, higher bilirubin levels at LT and use of anti-seizure medication predicted lower cognitive function scores. HRQOL following pediatric LT is related to medical and demographic variables.
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影响因子：
1.3
作者：
Fredericks, Emily M.;Magee, John C.;Lopez, M. James
通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
Kotagal, U