The fast and slow ups and downs of HCN channel regulation.
The fast and slow ups and downs of HCN channel regulation.
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DOI：
10.4161/chan.4.3.11630
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Chetkovich DM
中科院分区：
文献类型：
--
作者：
Lewis AS;Estep CM;Chetkovich DM
超极化激活的环核苷酸门控（HCN）通道（h通道）构成了超极化激活电流的分子基础，Ih和h通道的调节有助于改变哺乳动物大脑和心脏正常功能的细胞特性。在生理和病理条件下，许多机制都是h通道调制的基础，导致了门控、动力学、表面表达、通道电导或h通道亚基组成的明显变化。在这里，我们提供了一个集中审查的当代机制的h通道调节，重点是最近发现的相互作用的蛋白质，如TRIP8b。本综述旨在为生理学家提供全面的资源，以提供不同生物学模型中Ih功能重要变化的潜在分子机制，并为分子生物学家描绘与正常功能和疾病状态下复杂调节机制相关的预测h通道变化。
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) form the molecular basis for the hyperpolarization-activated current, Ih and modulation of h channels contributes to changes in cellular properties critical for normal functions in the mammalian brain and heart. Numerous mechanisms underlie h channel modulation during both physiological and pathological conditions, leading to distinct changes in gating, kinetics, surface expression, channel conductance or subunit composition of h channels. Here we provide a focused review examining contemporary mechanisms of h channel regulation, with an emphasis on recent findings regarding interacting proteins such as TRIP8b. This review is intended to serve as a comprehensive resource for physiologists to provide potential molecular mechanisms underlying functionally important changes in Ih in different biological models, as well as for molecular biologists to delineate the predicted h channel changes associated with complex regulatory mechanisms in both normal function and in disease states.
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影响因子：
4.8
作者：
Chen, S;Liang, MC;Ting, AE
通讯作者：
Ting, AE
DOI：
10.1152/physiologyonline.2002.17.1.32
发表时间：
2002-02-01
期刊：
NEWS IN PHYSIOLOGICAL SCIENCES
影响因子：
--
作者：
Accili, EA;Proenza, C;DiFrancesco, D
通讯作者：
DiFrancesco, D
DOI：
10.1152/ajpheart.00154.2009
发表时间：
2009-07-01
影响因子：
4.8
作者：
Brandt, Mathias C.;Endres-Becker, Jeannette;Hoppe, Uta C.
通讯作者：
Hoppe, Uta C.
影响因子：
56.9
作者：
Baukrowitz, T;Schulte, U;Fakler, B
通讯作者：
Fakler, B
影响因子：
64.5
作者：
Abbott, GW;Butler, MH;Goldstein, SAN
通讯作者：
Goldstein, SAN