Incorporation of heparin into biomaterials.
Incorporation of heparin into biomaterials.
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DOI：
10.1016/j.actbio.2013.08.045
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发表时间：
2014-04
影响因子：
9.7
通讯作者：
Sakiyama-Elbert, Shelly E.
中科院分区：
文献类型：
--
作者：
Sakiyama-Elbert, Shelly E.
本文综述了肝素掺入生物材料的研究进展，重点介绍了肝素基生物材料在药物传递和聚合物网络自组装中的应用。肝素与生物材料的结合最初是为了减少与血液接触的材料的血栓性而探索的。为这些应用开发的许多共轭策略今天在其他应用中仍然很流行。最近肝素已被偶联到生物材料中用于药物输送应用。许多递送方法利用了肝素与多种生长因子结合的能力，保护它们免受降解，并增强它们与细胞表面受体的相互作用。最近，利用肝素作为支架制造的基础聚合物也被探索，通常利用肝素与肽或蛋白质的非共价结合来促进水凝胶网络的自组装。本综述将重点介绍这些领域的最新进展。
This review provides an overview on the incorporation of heparin into biomaterials with a focus on drug delivery and the use of heparin-based biomaterials for self-assembly of polymer networks. Heparin conjugation to biomaterials was originally explored to reduce the thrombogenicity of materials in contact with blood. Many of the conjugation strategies that were developed for these applications are still popular today for other applications. More recently heparin has been conjugated to biomaterials for drug delivery applications. Many of the delivery approaches have taken advantage of the ability of heparin to bind to a wide variety of growth factors, protect them from degradation and to potentiate their interactions with cell surface receptors. More recently, the use of heparin as a base polymer for scaffold fabrication has also been explored, often utilizing non-covalent binding of heparin with peptides or proteins to promote self-assembly of hydrogel networks. This review will highlight recent advances in each of these areas.
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工程细胞材料界面，用于人类多能干细胞长期扩张。
影响因子：
14
作者：
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