PrEParing for long-acting injectable PrEP in the South: perspectives from healthcare providers in Georgia.
PrEParing for long-acting injectable PrEP in the South: perspectives from healthcare providers in Georgia.
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DOI：
10.1080/09540121.2020.1810616
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发表时间：
2021-06
期刊：
影响因子：
1.7
通讯作者：
Siegler AJ
中科院分区：
文献类型：
--
作者：
Xavier Hall CD;Smith JC;Driggers RA;Stoller B;Khan Z;Li J;Ignatius EH;Siegler AJ
新的暴露前预防 (PrEP) 方式，例如长效注射剂 PrEP (LAI-PrEP)，有望加强对 HIV 传播的预防；然而，类似的生物医学干预措施尚未得到医疗保健提供者或受艾滋病毒影响最严重的人群的普遍采用。这项定性研究探讨了医疗保健提供者在推出 LAI-PrEP 时的考虑因素。对每日口服 PrEP 处方的临床医生进行了 11 次关键信息的深度访谈。参与者审查了当前提出的 LAI 方案，并被要求反思其对临床实践的影响。访谈内容逐字记录并按主题编码，结果使用实施研究综合框架 (CFIR) 进行组织。所有参与者都表示有兴趣开出 LAI-PrEP 处方，并预计至少有一些患者会感兴趣。参与者确定了干预措施的特征、内部干预设置和外部干预设置，这些特征将对 LAI-PrEP 规模化产生影响。南方的临床医生对成功推出未来 PrEP 方案的挑战和机遇有着独特的见解。将这些见解纳入 CFIR 框架凸显了 LAI-PrEP 的细微差别，包括成本障碍和获得现场医疗服务等结构性问题。应对这些挑战对于确保成功实施新的 PrEP 制剂至关重要。
New modalities of Pre-exposure Prophylaxis (PrEP) such as long-acting injectable PrEP (LAI-PrEP) promise increased prevention of HIV transmission; however, similar biomedical interventions have not been met with universal adoption by healthcare providers or populations most affected by HIV. This qualitative study explores healthcare provider considerations for the rollout of LAI-PrEP. Eleven key-informant in-depth interviews were conducted with clinicians who prescribe daily oral PrEP. Participants reviewed a currently proposed LAI regimen and were asked to reflect on its implications for their clinical practice. Interviews were transcribed verbatim and thematically coded, with results organized using the Consolidated Framework for Implementation Research (CFIR). All participants expressed interest in prescribing LAI-PrEP and anticipated that at least some patients would be interested. Participants identified characteristics of the intervention, inner intervention setting, and outer intervention setting that will be influential in bringing LAI-PrEP to scale. Clinicians in the South have unique insights into the challenges of and opportunities for successful rollout of future PrEP regimens. Bringing these insights into a CFIR framework highlights the nuances surrounding LAI-PrEP, including structural concerns such as cost barriers and access to in-person healthcare services. It is critical to address these challenges to ensure successful implementation of new PrEP formulations.
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DOI：
10.1186/1748-5908-4-50
发表时间：
2009-08-07
期刊：
Implementation science : IS
影响因子：
--
作者：
Damschroder LJ;Aron DC;Keith RE;Kirsh SR;Alexander JA;Lowery JC
通讯作者：
Lowery JC
影响因子：
4.4
作者：
Kuhns LM;Hotton AL;Schneider J;Garofalo R;Fujimoto K
通讯作者：
Fujimoto K
影响因子：
16.1
作者：
Markowitz, Martin;Frank, Ian;Spreen, William R.
通讯作者：
Spreen, William R.
影响因子：
4.6
作者：
Muessig, Kathryn E.;Nekkanti, Manali;Bauermeister, Jose;Bull, Sheana;Hightow-Weidman, Lisa B.
通讯作者：
Hightow-Weidman, Lisa B.
影响因子：
5.6
作者：
Siegler, Aaron J.;Mouhanna, Farah;Sullivan, Patrick S.
通讯作者：
Sullivan, Patrick S.