Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites.
Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites.
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羟基磷灰石表面功能化对聚（L - 丙交酯）及聚（L - 丙交酯 - 共 - 乙交酯）基复合材料热性能和生物学性能的影响
DOI：
10.3390/ijms21186711
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发表时间：
2020-09-13
影响因子：
5.6
通讯作者：
Rudnicka K
中科院分区：
文献类型：
--
作者：
Gazińska M;Krokos A;Kobielarz M;Włodarczyk M;Skibińska P;Stępak B;Antończak A;Morawiak M;Płociński P;Rudnicka K
Novel biocomposites of poly(L-lactide) (PLLA) and poly(l-lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l-lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 °C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled.
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影响因子：
3.4
作者：
Li, Feng-Jiao;Zhang, Shui-Dong;Wang, Jun-Zhe
通讯作者：
Wang, Jun-Zhe
影响因子：
2.9
作者：
Jiang Liuyun;Jiang Lixin;Li Ye
通讯作者：
Li Ye
DOI：
10.1016/j.msec.2019.04.073
发表时间：
2019-09-01
影响因子：
7.9
作者：
Castillo-Cruz, O.;Aviles, F.;Peponi, L.
通讯作者：
Peponi, L.
影响因子：
2.9
作者：
Bunney PE;Zink AN;Holm AA;Billington CJ;Kotz CM
通讯作者：
Kotz CM
影响因子：
12.7
作者：
Gong T;Xie J;Liao J;Zhang T;Lin S;Lin Y
通讯作者：
Lin Y