Rapid senescence-like response after acute injury.
Rapid senescence-like response after acute injury.
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DOI：
10.1111/acel.13201
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发表时间：
2020-09
期刊：
影响因子：
7.8
通讯作者：
Raju RP
中科院分区：
文献类型：
--
作者：
Chu X;Wen J;Raju RP
细胞衰老是一种不可逆的生长停滞状态。胚胎发育中的短期程序性衰老和衰老中的缓慢进展衰老都得到了很好的描述。然而，生物体的急性衰老尚不清楚。我们推测，由于全身缺氧和营养缺乏造成失血性休克损伤（HI），导致严重失血导致器官功能障碍，可能导致体内急性衰老。我们的实验首次证明，在失血性休克后不到五小时内，大鼠肝脏迅速出现了抗衰老药物反应性的衰老样反应。我们得出的结论是，观察到的衰老或假衰老对于维持损伤后的组织稳态是必要的。在这项研究中，我们发现遭受失血性休克（一种急性损伤）的老鼠会在几个小时内出现类似衰老的反应。用衰老剂治疗这些动物会降低存活率，这表明观察到的衰老或假衰老可能是损伤后组织稳态所必需的。
Cellular senescence is a state of irreversible growth arrest. Short‐term programmed senescence such as in embryonic development and slowly progressing senescence as in aging are both well described. However, acute senescence in living organisms is not well understood. We hypothesized that hemorrhagic shock injury (HI) caused by whole body hypoxia and nutrient deprivation, resulting in organ dysfunction due to severe blood loss, could lead to acute senescence in vivo. Our experiments, for the first time, demonstrate a rapidly emerged, senolytics‐responsive, senescence‐like response in the rat liver in less than five hr following hemorrhagic shock. We conclude that the senescence, or pseudosenescence, observed is necessary to maintain tissue homeostasis following the injury. In this study, we show that rats subjected to hemorrhagic shock, an acute injury, develop a senescence‐like response within a few hours. Treatment of these animals with senolytics reduced survival, suggesting that the senescence, or pseudosenescence, observed may be necessary for tissue homeostasis following the injury.
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影响因子：
7.8
作者：
Zhu Y;Tchkonia T;Pirtskhalava T;Gower AC;Ding H;Giorgadze N;Palmer AK;Ikeno Y;Hubbard GB;Lenburg M;O'Hara SP;LaRusso NF;Miller JD;Roos CM;Verzosa GC;LeBrasseur NK;Wren JD;Farr JN;Khosla S;Stout MB;McGowan SJ;Fuhrmann-Stroissnigg H;Gurkar AU;Zhao J;Colangelo D;Dorronsoro A;Ling YY;Barghouthy AS;Navarro DC;Sano T;Robbins PD;Niedernhofer LJ;Kirkland JL
通讯作者：
Kirkland JL
影响因子：
3.7
作者：
HAYFLICK, L;MOORHEAD, PS
通讯作者：
MOORHEAD, PS
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
21.3
作者：
Campaner, Stefano;Doni, Mirko;Amati, Bruno
通讯作者：
Amati, Bruno
影响因子：
11.1
作者：
Hickson, LaTonya J.;Prata, Larissa G. P. Langhi;Kirkland, James L.
通讯作者：
Kirkland, James L.