N (6)-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development.
N (6)-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development.
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N6-甲基腺苷修饰：抗癌药物开发的新药理学靶点
DOI：
10.1016/j.apsb.2018.06.001
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Wan G
中科院分区：
文献类型：
--
作者：
Niu Y;Wan A;Lin Z;Lu X;Wan G
N6-甲基腺苷（m6 A）修饰是人类mRNA分子最普遍的修饰。它是可逆的，通过调节m6 A修饰甲基转移酶，脱甲基酶和蛋白质，优先识别m6 A修饰作为“作家”，“擦除器”和“读者”，分别。m6 A修饰关键调节子的表达水平改变会显著影响其功能，导致细胞和生物体中的显著表型变化。最近的研究表明，m6 A修饰在多种人类癌症的代谢、干细胞自我更新和转移的调节中起着重要作用。本文综述了m6 A修饰在人类肿瘤中的潜在作用，并总结了其分子机制。此外，我们将通过针对癌症药物开发的关键m6 A修饰调节剂来突出潜在的治疗方法。N6-甲基腺苷（m6 A）修饰是mRNA中最普遍的内部修饰，通过影响增殖、侵袭、耐药性和免疫抑制在癌症中发挥重要作用。本文综述了m6 A修饰对肿瘤发生、发展的影响，并阐述了m6 A修饰抑制剂在各种肿瘤中的作用机制。m6 A修饰的关键调控因子可能成为抗癌药物开发的潜在治疗靶点。
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”, “erasers” and “readers”, respectively. Altered expression levels of the m6A modification key regulators substantially affect their function, leading to significant phenotype changes in the cell and organism. Recent studies have proved that the m6A modification plays significant roles in regulation of metabolism, stem cell self-renewal, and metastasis in a variety of human cancers. In this review, we describe the potential roles of m6A modification in human cancers and summarize their underlying molecular mechanisms. Moreover, we will highlight potential therapeutic approaches by targeting the key m6A modification regulators for cancer drug development. N6-Methyladenosine (m6A) modification is the most pervasive internal modification in mRNA and plays an important role in cancers via affecting proliferation, invasion, drug resistance and immunosuppression. This review summarizes the pathogenesis and development of cancer that are mainly affected by m6A modification, and demonstrates the mechanisms of m6A modification inhibitors in various cancers. The key regulators for m6A modification may act as potential therapeutic targets for anti-cancer drug development.
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影响因子：
64.8
作者：
Han, Zhifu;Niu, Tianhui;Chai, Jijie
通讯作者：
Chai, Jijie
影响因子：
4.5
作者：
Edelheit S;Schwartz S;Mumbach MR;Wurtzel O;Sorek R
通讯作者：
Sorek R
影响因子：
23.9
作者：
Batista, Pedro J.;Molinie, Benoit;Wang, Jinkai;Qu, Kun;Zhang, Jiajing;Li, Lingjie;Bouley, Donna M.;Lujan, Ernesto;Haddad, Bahareh;Daneshvar, Kaveh;Carter, Ava C.;Flynn, Ryan A.;Zhou, Chan;Lim, Kok-Seong;Dedon, Peter;Wernig, Marius;Mullen, Alan C.;Xing, Yi;Giallourakis, Cosmas C.;Chang, Howard Y.
通讯作者：
Chang, Howard Y.
DOI：
10.1126/science.1151710
发表时间：
2007-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerken T;Girard CA;Tung YC;Webby CJ;Saudek V;Hewitson KS;Yeo GS;McDonough MA;Cunliffe S;McNeill LA;Galvanovskis J;Rorsman P;Robins P;Prieur X;Coll AP;Ma M;Jovanovic Z;Farooqi IS;Sedgwick B;Barroso I;Lindahl T;Ponting CP;Ashcroft FM;O'Rahilly S;Schofield CJ
通讯作者：
Schofield CJ
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.