Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.
Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.
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DOI：
10.1016/j.ekir.2018.06.005
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发表时间：
2018-11
影响因子：
6
通讯作者：
Lash JP
中科院分区：
文献类型：
--
作者：
Ricardo AC;Chen J;Singh M;Heiss G;Raij L;Ramos A;Redline S;Rosas SE;Shah N;Sotres-Alvarez D;Zee P;Daviglus M;Lash JP
尽管已发现睡眠呼吸障碍与较高的尿白蛋白排泄相关，但尚未在西班牙裔/拉丁裔人群中评价这种相关性，与非西班牙裔相比，西班牙裔/拉丁裔人群的终末期肾病负担较高。我们评估了美国西班牙裔/拉丁裔人群中睡眠呼吸障碍与蛋白尿的相关性。这是一项对西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）参与者基线数据的横断面研究，该研究是一项基于人群的研究，在4个美国社区招募了16，415名成年人。使用家用睡眠呼吸暂停监测仪进行夜间记录，并使用呼吸暂停低通气指数（AHI; 3%去饱和）的3个阈值（≥5、≥15和≥30）定义睡眠呼吸障碍。白蛋白尿定义为尿白蛋白/肌酐比值≥30 mg/g。共有12，572名参与者提供了完整的数据供分析。经年龄和性别校正的蛋白尿患病率为9.1%。平均年龄为41岁，48%为男性。与无蛋白尿的个体相比，有蛋白尿的个体的睡眠呼吸障碍的年龄和性别校正患病率更高（AHI ≥5的分别为36%和25%，AHI ≥15的分别为18%和9%，AHI ≥30的分别为9%和4%）。在多变量logistic回归分析中，与AHI <5、<15和<30的患者相比，AHI ≥5、≥ 15和≥30与蛋白尿的几率更大相关（比值比[OR] 1.42，95%置信区间[CI]：1.14−1.76; OR：1.71，95% CI：1.33−2.20; OR：1.93，95% CI 1.34−2.79）。这种关联因西班牙裔/拉丁裔背景组而异。在美国西班牙裔/拉丁裔中，睡眠呼吸障碍与白蛋白尿发生率较高独立相关。
Although sleep-disordered breathing has been found to be associated with higher urine albumin excretion, this association has not been evaluated in Hispanic/Latino populations, which experience a high burden of end-stage renal disease compared with non-Hispanics. We evaluated the association of sleep-disordered breathing with prevalent albuminuria among US Hispanics/Latinos. This was a cross-sectional study of baseline data from participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based study that enrolled 16,415 adults in 4 US communities. Sleep-disordered breathing was assessed using a home sleep apnea monitor for overnight recording and was defined using 3 thresholds of the apnea−hypopnea index (AHI; 3% desaturation): ≥5, ≥15, and ≥30. Albuminuria was defined as a urine albumin-to-creatinine ratio of ≥30 mg/g. There were 12,572 participants with complete data available for analysis. The age- and sex-adjusted prevalence of albuminuria was 9.1%. Mean age was 41 years, and 48% were men. Age- and sex-adjusted prevalence of sleep-disordered breathing was higher among individuals with albuminuria compared with those without albuminuria (36% vs. 25% had AHI ≥5, 18% vs. 9% had AHI ≥15, and 9% vs. 4% had AHI ≥30). In multivariable logistic regression analyses, AHIs ≥5, ≥15, and ≥30 were associated with greater odds of albuminuria compared with those with AHIs <5, <15, and <30 (odds ratio [OR] 1.42, 95% confidence interval [CI]: 1.14−1.76; OR: 1.71, 95% CI: 1.33−2.20; and OR 1.93, 95% CI 1.34−2.79), respectively. This association varied by Hispanic/Latino background group. In US Hispanic/Latinos, sleep-disordered breathing was independently associated with higher odds of prevalent albuminuria.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
DOI：
10.1186/1476-9255-10-13
发表时间：
2013
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Baessler A;Nadeem R;Harvey M;Madbouly E;Younus A;Sajid H;Naseem J;Asif A;Bawaadam H
通讯作者：
Bawaadam H
影响因子：
5.6
作者：
Lavange, Lisa M.;Kalsbeek, William D.;Sorlie, Paul D.;Aviles-Santa, Larissa M.;Kaplan, Robert C.;Barnhart, Janice;Liu, Kiang;Giachello, Aida;Lee, David J.;Ryan, John;Criqui, Michael H.;Elder, John P.
通讯作者：
Elder, John P.
影响因子：
3.3
作者：
Hanly, Patrick
通讯作者：
Hanly, Patrick
影响因子：
37.8
作者：
Klausen, K;Borch-Johnsen, K;Jensen, JS
通讯作者：
Jensen, JS