Prognostic value of metastin expression in human pancreatic cancer.
Prognostic value of metastin expression in human pancreatic cancer.
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DOI：
10.1186/1756-9966-28-9
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发表时间：
2009-01-21
影响因子：
11.3
通讯作者：
Uemoto, Shinji
中科院分区：
文献类型：
--
作者：
Nagai, Kazuyuki;Doi, Ryuichiro;Katagiri, Fumihiko;Ito, Tatsuo;Kida, Atsushi;Koizumi, Masayuki;Masui, Toshihiko;Kawaguchi, Yoshiya;Tomita, Kenji;Oishi, Shinya;Fujii, Nobutaka;Uemoto, Shinji
KiSS-1被鉴定为黑色素瘤细胞中的转移抑制基因。KiSS-1基因产物（metastin）是从人胎盘中分离的，作为G蛋白偶联受体GPR 54的配体。metastin和GPR 54在肿瘤进展中的作用尚未完全了解。我们研究了metastin和GPR 54在胰腺癌中表达的临床意义。我们评估了2003年7月至2007年5月在京都大学附属医院接受切除术的53例胰腺导管腺癌组织中metastin和GPR 54的免疫组化表达。在连续23例患者中，术前用酶免疫法测定血浆metastin水平。免疫组化结果显示，13例（24.5%）肿瘤表达metastin，30例（56.6%）肿瘤表达GPR 54。对于metastin和GPR 54表达均为阴性的肿瘤显著大于对于metastin或GPR 54均为阳性的肿瘤（p = 0.047）。转移素阳性肿瘤患者的复发率低于转移素阴性肿瘤患者（38.5% vs 70.0%，p = 0.04）。metastin和GPR 54的强表达与较长的存活显著相关（p = 0.02）。胰腺癌的Metastin表达是延长生存期的独立预后因素（风险比，2.1; 95%置信区间，1.1-4.7; p = 0.03），并且具有高血浆metastin水平的患者（n = 6）在手术切除后没有死亡。胰腺癌中metastin和GPR 54的强表达与更长的生存期相关Metastin表达是胰腺癌患者生存的独立预后因素。血浆metastin水平可作为胰腺癌的无创性预后评估指标。
KiSS-1 was identified as a metastasis-suppressing gene in melanoma cells. The KiSS-1 gene product (metastin) was isolated from human placenta as the ligand of GPR54, a G-protein-coupled receptor. The role of metastin and GPR54 in tumor progression is not fully understood. We investigated the clinical significance of metastin and GPR54 expression in pancreatic cancer. We evaluated immunohistochemical expression of metastin and GPR54 in pancreatic ductal adenocarcinoma tissues obtained from 53 consecutive patients who underwent resection between July 2003 and May 2007 at Kyoto University Hospital. In 23 consecutive patients, the plasma metastin level was measured before surgery by enzyme immunoassay. Strong immunohistochemical expression of metastin was detected in 13 tumors (24.5%), while strong expression of GPR54 was detected in 30 tumors (56.6%). Tumors that were negative for both metastin and GPR54 expression were significantly larger than tumors that were positive for either metastin or GPR54 (p = 0.047). Recurrence was less frequent in patients who had metastin-positive tumors compared with those who had metastin-negative tumors (38.5% versus 70.0%, p = 0.04). Strong expression of metastin and GPR54 was significantly correlated with longer survival (p = 0.02). Metastin expression by pancreatic cancer was an independent prognostic factor for longer survival (hazard ratio, 2.1; 95% confidence interval, 1.1–4.7; p = 0.03), and the patients with a high plasma metastin level (n = 6) did not die after surgical resection. Strong expression of metastin and GPR54 by pancreatic cancer is associated with longer survival. Metastin expression is an independent prognostic factor for the survival of pancreatic cancer patients. The plasma metastin level could become a noninvasive prognostic factor for the assessment of pancreatic cancer.
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