Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy.
Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy.
复制标题
基于图像的肥厚型心肌病心血管阻塞的计算血流动力学分析。
DOI：
10.3389/fphys.2021.787082
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发表时间：
2021
影响因子：
4
通讯作者：
Quarteroni A
中科院分区：
文献类型：
--
作者：
Fumagalli I;Vitullo P;Vergara C;Fedele M;Corno AF;Ippolito S;Scrofani R;Quarteroni A
肥厚性心肌病（HCM）是一种以心肌异常增厚为特征的病理状态。当影响到室间隔的中基底部分时，它被命名为肥厚性梗阻性心肌病（HOCM），因为它在左心室流出道引起血流阻塞。在任何类型的HCM中，心肌功能都可能受到损害，可能导致心源性死亡。在这项研究中，我们通过计算分析研究了不同类型HCM患者的血流动力学。目的是量化这种病理对脑室内血流和压力梯度的影响，并提供潜在有用的信息来指导手术治疗的适应症和方式（隔膜切除术）。我们采用了一种基于图像的计算方法，将流体动力学模拟与几何和功能数据相结合，从标准的心脏电影mri采集中重建。我们表明，通过我们的方法，我们可以更好地理解由于左心室形态和功能方面的异常而引起的室内血流动力学的病理生理行为。我们调查的主要结果是：(a)对与HCM相关的血流速度、压力和应力分布进行了详细的患者特异性分析；(b)基于计算的HCM患者分类，可以补充当前HOCM的诊断和治疗临床指南。
Hypertrophic Cardiomyopathy (HCM) is a pathological condition characterized by an abnormal thickening of the myocardium. When affecting the medio-basal portion of the septum, it is named Hypertrophic Obstructive Cardiomyopathy (HOCM) because it induces a flow obstruction in the left ventricular outflow tract. In any type of HCM, the myocardial function can become compromised, possibly resulting in cardiac death. In this study, we investigated with computational analysis the hemodynamics of patients with different types of HCM. The aim was quantifying the effects of this pathology on the intraventricular blood flow and pressure gradients, and providing information potentially useful to guide the indication and the modality of the surgical treatment (septal myectomy). We employed an image-based computational approach, integrating fluid dynamics simulations with geometric and functional data, reconstructed from standard cardiac cine-MRI acquisitions. We showed that with our approach we can better understand the patho-physiological behavior of intraventricular blood flow dynamics due to the abnormal morphological and functional aspect of the left ventricle. The main results of our investigation are: (a) a detailed patient-specific analysis of the blood velocity, pressure and stress distribution associated to HCM; (b) a computation-based classification of patients affected by HCM that can complement the current clinical guidelines for the diagnosis and treatment of HOCM.
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影响因子：
39.3
作者：
Elliott, Perry M.;Anastasakis, Aris;Watkins, Hugh
通讯作者：
Watkins, Hugh
DOI：
10.1002/cnm.3435
发表时间：
2021-04
影响因子：
2.1
作者：
Fedele M;Quarteroni A
通讯作者：
Quarteroni A
影响因子：
2.4
作者：
De Hart, J;Peters, GWM;Baaijens, FPT
通讯作者：
Baaijens, FPT
影响因子：
3.5
作者：
Fedele, Marco;Faggiano, Elena;Quarteroni, Alfio
通讯作者：
Quarteroni, Alfio
DOI：
10.1002/cnm.2474
发表时间：
2012-09-01
影响因子：
2.1
作者：
Astorino, Matteo;Hamers, Jeroen;Gerbeau, Jean-Frederic
通讯作者：
Gerbeau, Jean-Frederic