Different analgesic effects of adenosine between postoperative and neuropathic pain.
Different analgesic effects of adenosine between postoperative and neuropathic pain.
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DOI：
10.1007/s00776-012-0302-0
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发表时间：
2013-01
影响因子：
1.7
通讯作者：
Ogata, Tadanori
中科院分区：
文献类型：
--
作者：
Yamaoka, Gotaro;Horiuchi, Hideki;Morino, Tadao;Miura, Hiromasa;Ogata, Tadanori
腺苷是外周和中枢神经系统中的内源性神经调质。腺苷通过超极化神经元膜抑制疼痛信号。为了阐明腺苷对疼痛信号的影响，我们测试了两种神经性疼痛（脊髓压迫和坐骨神经慢性收缩）和术后疼痛（足底切口）的鞘内腺苷注射。在三种疼痛模型中，从术后24 h到1周，热刺激引起的戒断潜伏期明显缩短。手术后24 h鞘内注射Cl-腺苷后，在所有三种模型中均观察到疼痛感觉的显著改善。在术后72小时，鞘内注射氯-腺苷抑制痛觉过敏的两种神经病理性疼痛模型，但不在术后疼痛模型。腺苷A1 R信使RNA（mRNA）的表达显着降低足底切口模型。腺苷A1 R蛋白水平也较其他两种模型和正常对照组降低。这些结果表明，腺苷有效地抑制神经性疼痛的疼痛信号，但由于腺苷A1受体的减少，在术后疼痛中效果较差。
Adenosine is an endogenous neuromodulator in both the peripheral and central nervous systems. Adenosine inhibits pain signals by hyperpolarizing neuronal membrane. To clarify the effects of adenosine on pain signals, we tested intrathecal adenosine injection in two neuropathic pains (spinal cord compression and chronic constriction of sciatic nerve) and postoperative pain (plantar incision). In all three kinds of pain models, significant shortening of withdrawal latencies to thermal stimulation were detected from 24 h to 1 week after the surgery. Significant improvements of pain sensation were observed in all three models after intrathecal injection of Cl-adenosine 24 h after surgery. At 72 h after surgery, intrathecal Cl-adenosine injection inhibited hyperalgesia in the two neuropathic pain models but not in the postoperative pain model. Adenosine A1R messenger RNA (mRNA) expression significantly decreased in the plantar incision model. Adenosine A1R protein levels also decreased compared with the other two models and normal control. These results suggest that adenosine effectively inhibits pain signals in neuropathic pain but is less effective in postoperative pain because of the decrease in adenosine A1 receptors.
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影响因子：
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DOI：
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