Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts.
Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts.
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旋毛虫幼虫来源的细胞外囊泡促进巨噬细胞极化为M2b型并抑制成纤维细胞活化
DOI：
10.3389/fimmu.2022.974332
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
旋毛虫（Trichinella spiralis，T.螺旋体）是一种全球分布的食源性寄生虫，感染后可与宿主长期共存。旋毛虫分泌物可调节宿主的免疫反应和成纤维细胞，但具体机制尚不清楚。本研究旨在探讨T.研究了旋毛虫幼虫来源的细胞外囊泡（EVs）及其在旋毛虫幼虫发育过程中的关键miRNAs。螺旋体-宿主相互作用在本研究中，我们发现T. spiralis幼虫以及miR-1 - 3p和let-7 - 5p在T.旋毛虫幼虫衍生的EV，可以促进骨髓巨噬细胞向M2b型极化，同时抑制成纤维细胞的活化。这些发现将有助于进一步了解T. spiralis-host相互作用
Trichinella spiralis (T. spiralis) is a globally distributed food-borne parasite that can coexist with the host for a long time after infection. Trichinella-derived secretions can regulate the immune response and fibroblasts of the host, but the specific mechanisms involved are still unclear. The purpose of this study was to investigate the role of T. spiralis larvae-derived extracellular vesicles (EVs) and their key miRNAs in the process of T. spiralis–host interaction. In this study, we found that the EVs of T. spiralis larvae, as well as miR-1-3p and let-7-5p, expressed in T. spiralis larvae-derived EVs, can promote the polarization of bone marrow macrophages to M2b type while inhibiting the activation of fibroblasts. These findings will contribute to further understanding of the molecular mechanisms underlying T. spiralis–host interactions.
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作者：
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DOI：
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