High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant.
High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant.
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DOI：
10.1038/s41467-023-41447-8
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发表时间：
2023-09-12
影响因子：
16.6
通讯作者：
Wang, Xiaodan
中科院分区：
文献类型：
--
作者：
Wang, Yuxi;Li, Mingshan;Ying, Jiahan;Shen, Jie;Dou, Daolong;Yin, Meizhen;Whisson, Stephen C.;Birch, Paul R. J.;Yan, Shuo;Wang, Xiaodan
马铃薯晚疫病是由马铃薯晚疫病菌引起的一种世界性病害。与其他植物病原菌不同，双链RNA(DsRNA)很难被致病疫霉摄取，这是利用dsRNA进行疾病控制的关键障碍。基于dsRNA和植物激发子，设计了一种用于马铃薯晚疫病防治的自组装多组分纳米生物保护剂。纳米技术克服了致病疫霉的dsRNA传递瓶颈，延长了RNAi的保护窗口。纳米dsRNA对感染的保护作用源于一种协同机制，该机制增强了dsRNA的稳定性，并优化了其有效的细胞内递送。此外，纳米激活的激发子增强了植物的内吞作用，放大了植物的系统防御反应。DsRNA和激发子的共传递通过抑制病原菌和提高植物防御机制两个方面提供了保护作用。多组分纳米生物保护剂在田间条件下表现出比商业合成农药更好的防治效果。这项工作提出了一种生态友好型战略，以管理毁灭性的植物病虫害。马铃薯晚疫病菌不同于其他植物病原菌，致病疫霉几乎不能结合dsRNA，这是利用dsRNA防治马铃薯晚疫病的关键障碍。在此，作者设计了一种用于马铃薯晚疫病防治的自组装多组分纳米生物保护剂。
Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests. Unlike the other plant pathogens, Phytophtora infestans, the causative pathogen of potato late blight, can hardly take up dsRNA, which is a key obstacle in using dsRNA for disease control. Here, the authors design a self-assembled multicomponent nano-bioprotectant for potato late blight management.
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DOI：
10.1111/nph.16650
发表时间：
2020-10
期刊：
The New phytologist
影响因子：
--
作者：
Boevink PC;Birch PRJ;Turnbull D;Whisson SC
通讯作者：
Whisson SC
影响因子：
3.2
作者：
Kalyandurg, Pruthvi B.;Sundararajan, Poorva;Vetukuri, Ramesh R.
通讯作者：
Vetukuri, Ramesh R.
荧光纳米颗粒传递双链RNA以实现害虫的遗传控制
影响因子：
29.4
作者：
He, Bicheng;Chu, Yuan;Shen, Jie
通讯作者：
Shen, Jie
影响因子：
6.5
作者：
Gachon, C;Saindrenan, P
通讯作者：
Saindrenan, P
跨王国RNA贩运和环境RNAi-Nature的蓝图，用于现代作物保护策略。
影响因子：
5.4
作者：
Cai Q;He B;Kogel KH;Jin H
通讯作者：
Jin H