A complex relationship: the interaction among symbiotic microbes, invading pathogens, and their mammalian host.
A complex relationship: the interaction among symbiotic microbes, invading pathogens, and their mammalian host.
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作者：
微生物和哺乳动物宿主之间的共生关系对于维持体内平衡至关重要。胃肠道内的共生微生物为宿主提供一系列益处，包括促进宿主免疫。宿主和共生微生物的协调努力阻止了许多入侵病原体的定殖和存活。然而，病原体已经设计出克服这些机制的策略。此外，一些病原体可以劫持宿主激素和细菌自诱导物来诱导毒力性状。种内和种间（细菌：细菌）和界间（细菌：宿主）的交流协调了共生微生物、入侵病原体及其哺乳动物宿主之间的复杂关系。深入了解这种沟通将为靶向抗菌治疗的发展提供基础。
Symbiosis between microbes and their mammalian host is vital to maintaining homeostasis. Symbiotic microbes within the gastrointestinal tract provide an array of benefits to the host, including promotion of host immunity. A coordinated effort of the host and symbiotic microbes deters the colonization and survival of many invading pathogens. However, pathogens have devised strategies to overcome these mechanisms. Furthermore, some pathogens can hijack host hormones and bacterial autoinducers to induce virulence traits. Intra- and inter-species (bacteria: bacteria) and inter-kingdom (bacteria: host) communication orchestrates the complex relationship among symbiotic microbes, invading pathogens, and their mammalian host. Insight into this communication will provide a foundation for the development of targeted antimicrobial therapies.
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影响因子：
3.6
作者：
Diggle, SP;Winzer, K;Williams, P
通讯作者：
Williams, P
影响因子：
64.5
作者：
ENGEBRECHT, J;NEALSON, K;SILVERMAN, M
通讯作者：
SILVERMAN, M
DOI：
10.1073/pnas.81.13.4154
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ENGEBRECHT, J;SILVERMAN, M
通讯作者：
SILVERMAN, M
DOI：
10.1073/pnas.0507488102
发表时间：
2005-10-18
影响因子：
11.1
作者：
Karginov, VA;Nestorovich, EM;Bezrukov, SM
通讯作者：
Bezrukov, SM
影响因子：
2.2
作者：
Carey, Christine M.;Kostrzynska, Magdalena;Thompson, Stacey
通讯作者：
Thompson, Stacey