Motor Cortical Network Flexibility is Associated With Biomechanical Walking Impairment in Chronic Stroke.
Motor Cortical Network Flexibility is Associated With Biomechanical Walking Impairment in Chronic Stroke.
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DOI：
10.1177/15459683211046272
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发表时间：
2021-12
影响因子：
4.2
通讯作者：
Borich MR
中科院分区：
文献类型：
--
作者：
Palmer JA;Kesar TM;Wolf SL;Borich MR
无法根据任务需求或环境背景的变化灵活调节运动行为是中风后运动障碍和活动功能障碍的普遍特征。本研究的目的是使用脑电图（EEG）测量经颅磁刺激（TMS）引起的皮质活动来测试下肢初级运动皮质（M1）网络的反应和调节能力，并评估它们与慢性中风步行功能的临床和生物力学测量的关系。在慢性中风和年龄匹配的对照组中，在休息和主动同侧跖屈期间对运动皮层（M1）兴奋性进行经颅磁刺激（TMS）评估。 TMS 诱发的运动皮质网络相互作用通过同步脑电图 (EEG) 进行量化，作为 TMS 后 (0-300ms) beta (15-30Hz) 双边覆盖 M1 的电极之间的一致性。我们比较了休息和活动状态下各组之间 TMS 诱发的一致性，并测试了与中风后运动损伤、麻痹性推进步态缺陷以及麻痹性腿部运动诱发电位 (MEP) 存在的关联。与对照组（n=9、68±6岁，F=3）相比，中风（n=14、66±9岁，F=4）显示出较低的TMS诱发的皮质一致性和活动依赖性调节。 TMS 诱发的一致性的钝化和非典型调节与行走期间产生推进力的下麻痹踝力矩和麻痹 MEP 缺失有关。运动皮层网络对 TMS 做出反应并在运动活动期间进行调节的灵活性减弱与偏瘫肢体生物力学步行障碍明显相关，并且可能为了解慢性中风后活动能力缺陷的神经力学基础提供有用的见解。
The inability to flexibly modulate motor behavior with changes in task demand or environmental context is a pervasive feature of motor impairment and dysfunctional mobility after stroke. The purpose of this study was to test the reactive and modulatory capacity of lower-limb primary motor cortical (M1) networks using electroencephalography (EEG) measures of cortical activity evoked by transcranial magnetic stimulation (TMS) and to evaluate their associations with clinical and biomechanical measures of walking function in chronic stroke. Transcranial magnetic stimulation (TMS) assessments of motor cortex (M1) excitability were performed during rest and active ipsilateral plantarflexion in chronic stroke and age-matched controls. TMS-evoked motor cortical network interactions were quantified with simultaneous electroencephalography (EEG) as the post-TMS (0-300ms) beta (15-30Hz) coherence between electrodes overlying M1 bilaterally. We compared TMS-evoked coherence between groups during rest and active conditions and tested associations with post-stroke motor impairment, paretic propulsive gait deficits, and the presence of paretic leg motor evoked potentials (MEPs). Stroke (n=14, 66 ±9 years, F=4) showed lower TMS-evoked cortical coherence and activity-dependent modulation compared to controls (n=9, 68±6 years, F=3). Blunted and atypical modulation of TMS-evoked coherence were associated with lower paretic ankle moments for propulsive force generation during walking and absent paretic MEPs. Blunted flexibility of motor cortical networks to react to TMS and modulate during motor activity is distinctly associated with paretic limb biomechanical walking impairment, and may provide useful insight into the neuromechanistic underpinnings of chronic post-stroke mobility deficits.
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影响因子：
4.2
作者：
Bowden, Mark G.;Balasubramanian, Chitralakshmi K.;Kautz, Steven A.
通讯作者：
Kautz, Steven A.
影响因子：
4.1
作者：
Fjell, Anders M.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
4.2
作者：
Palmer, Jacqueline A.;Wheaton, Lewis A.;Borich, Michael R.
通讯作者：
Borich, Michael R.
影响因子：
4.7
作者：
Palmer, Jacqueline A.;Needle, Alan R.;Binder-Macleod, Stuart A.
通讯作者：
Binder-Macleod, Stuart A.
DOI：
10.1016/j.clinph.2012.01.010
发表时间：
2012-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Groppa S;Oliviero A;Eisen A;Quartarone A;Cohen LG;Mall V;Kaelin-Lang A;Mima T;Rossi S;Thickbroom GW;Rossini PM;Ziemann U;Valls-Solé J;Siebner HR
通讯作者：
Siebner HR