Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice.
Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice.
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DOI：
10.1038/srep01483
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发表时间：
2013
影响因子：
4.6
通讯作者：
Howe, Charles L.
中科院分区：
文献类型：
--
作者：
Bergstrom, Rachel A.;Choi, Jee Hyun;Manduca, Armando;Shin, Hee-Sup;Worrell, Greg A.;Howe, Charles L.
小鼠EEG信号的视觉评分是耗时的，并且受观察者间重现性低的影响。行为性癫痫发作严重程度的Racine量表不能提供发作间期或亚临床癫痫样活动的信息。一个自动化的算法，用于小鼠脑电分析开发使用总信号的变化和小波分解，以确定尖峰，癫痫发作，和其他异常信号类型的单通道EEG收集红藻氨酸处理的小鼠。该算法在从经历失神发作的γ-丁内酯处理的小鼠收集的多通道EEG上进行了验证。与视觉评分相比，该算法以高保真度识别癫痫样活动，以99%的准确率和91%的精度正确分类尖峰和癫痫发作。该算法正确地识别了由36个皮层电极记录的失神型癫痫发作中的棘波放电焦点。该算法提供了一种可靠的和自动化的方法，用于定量多种类别的癫痫样活动的小鼠EEG，是可调的各种事件类型和癫痫发作类别。
Visual scoring of murine EEG signals is time-consuming and subject to low inter-observer reproducibility. The Racine scale for behavioral seizure severity does not provide information about interictal or sub-clinical epileptiform activity. An automated algorithm for murine EEG analysis was developed using total signal variation and wavelet decomposition to identify spike, seizure, and other abnormal signal types in single-channel EEG collected from kainic acid-treated mice. The algorithm was validated on multi-channel EEG collected from γ-butyrolacetone-treated mice experiencing absence seizures. The algorithm identified epileptiform activity with high fidelity compared to visual scoring, correctly classifying spikes and seizures with 99% accuracy and 91% precision. The algorithm correctly identifed a spike-wave discharge focus in an absence-type seizure recorded by 36 cortical electrodes. The algorithm provides a reliable and automated method for quantification of multiple classes of epileptiform activity within the murine EEG and is tunable to a variety of event types and seizure categories.
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影响因子：
5.3
作者：
Borges, K;Gearing, M;Dingledine, R
通讯作者：
Dingledine, R
影响因子：
5.6
作者：
CASCINO, GD;KELLY, PJ;TRENERRY, MR
通讯作者：
TRENERRY, MR
影响因子：
3.8
作者：
Chiu, AWL;Daniel, S;Bardakjian, BL
通讯作者：
Bardakjian, BL
影响因子：
5.6
作者：
Osorio, I;Frei, MG;Wilkinson, SB
通讯作者：
Wilkinson, SB
影响因子：
2.5
作者：
Choi, Jee Hyun;Koch, Klaus Peter;Shin, Hee-Sup
通讯作者：
Shin, Hee-Sup