Predisposing conditions for atrial fibrillation in atrial septal defect with and without operative closure.
Predisposing conditions for atrial fibrillation in atrial septal defect with and without operative closure.
复制标题
房间隔缺损（无论是否进行手术封堵）发生房颤的诱发条件。
DOI：
10.1016/s0002-9149(01)02160-9
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
José A. Sobrino
中科院分区：
文献类型：
--
作者：
J. Oliver;P. Gallego;A. González;F. Benito;J. Mesa;José A. Sobrino
本研究的目的是确定成人房间隔缺损(ASD)患者房颤(AF)的患病率和易感条件，并评估手术修复时年龄的影响。研究人群包括286名成人ASD患者，平均年龄(39.5±19)岁。所有患者均进行≥-1随访和多普勒超声心动图检查。192的患者在研究前1到34年接受了手术闭合。分析变量进入单变量(Mann-Whitney U)和多变量(逐步Logistic回归)模型，以评估房颤的独立预测因素。在接受手术治疗的患者中，房颤的发生率(15.6%)与非手术组(13.8%)相似(p=0.69)。多因素分析显示，年龄(RR1.9/10岁，95%可信区间1.3~2.7，p=0.001)，二尖瓣关闭不全(RR3.0，95%CI1.6~5.8，p=0.001)，左房扩大(RR2.8，每10 mm增大，95%CI1.5~5.2，p=0.001)，三尖瓣反流(RR1.9，每一程度反流，95%CI1.0~3.7，P=0.001)，P=0.04)是房颤的独立预测因素；然而，性别、解剖类型、缺损区大小、QP：QS、肺动脉压、右室内径、左室短轴缩短率和既往手术修复与晚期房颤的发生无关。在手术组中，手术时年龄和25岁是唯一独立于研究时年龄而预测房颤的因素(p=0.02)。
The aims of this study were to determine the prevalence and predisposing conditions for atrial fibrillation (AF) in adults with atrial septal defect (ASD) and to evaluate the influence of age at surgical repair. The study population consisted of 286 adults with ASD (mean age 39.5 ± 19 years). All patients had ≥1 follow-up visit and a Doppler echocardiographic study. One hundred ninety-two of the patients underwent surgical closure 1 to 34 years before the study. Analyzed variables were entered into univariate (Mann-Whitney U) and multivariate (stepwise logistic regression) models to assess independent predictors for AF. The prevalence of AF was similar in surgically treated patients (15.6%) and in the nonsurgical group (13.8%) (p = 0.69). Multivariate analysis showed that current age (RR 1.9 per each decade of age, 95% confidence interval [CI] 1.3 to 2.7, p = 0.001), mitral regurgitation (RR 3.0 per each degree of regurgitation, 95% CI 1.6 to 5.8, p = 0.001), left atrial enlargement (RR 2.8 per each 10 mm increase in size, 95% CI 1.5 to 5.2, p = 0.001), and tricuspid regurgitation (RR 1.9 per each degree of regurgitation, 95% CI 1.0 to 3.7, p = 0.04) were independent predictors of AF; however, gender, anatomic type, defect size, Qp:Qs, pulmonary artery pressure, right ventricular dimension, left ventricular shortening fraction, and prior surgical repair were not related to late AF development. In the surgical group, age >25 years at the time of surgery was the only predictor for AF independent of age at the time of the study (p = 0.02).
影响因子：
2.8
作者：
FURBERG, CD;PSATY, BM;RAUTAHARJU, PM
通讯作者：
RAUTAHARJU, PM
成人房间隔缺损的右心室功能。
DOI：
10.1016/0002-9149(81)90289-7
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
--
作者：
Liberthson,RR;Boucher,CA;Strauss,HW;Dinsmore,RE;McKusick,KA;Pohost,GM
通讯作者：
Pohost,GM
影响因子：
2.8
作者：
Kannel, WB;Wolf, PA;Levy, D
通讯作者：
Levy, D