Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery.
Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery.
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纳米颗粒和细胞渗透肽与皮肤的相互作用，以递送透皮药物。
DOI：
10.3109/09687688.2010.522203
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发表时间：
2010-10
影响因子：
--
通讯作者：
Singh M
中科院分区：
文献类型：
--
作者：
Desai P;Patlolla RR;Singh M
局部或透皮给药具有挑战性，因为皮肤是天然的保护屏障。因此，已经研究了几种方法来增加治疗分子进入和通过皮肤的渗透。一种方法是使用纳米颗粒输送系统。从脂质体和其他囊泡系统开始，已经开发了几种其他类型的纳米药物载体，如固体脂质纳米颗粒、纳米结构脂质载体、聚合物基纳米颗粒和用于皮肤病学应用的磁性纳米颗粒。这篇综述文章讨论了不同的颗粒系统如何相互作用并穿透皮肤屏障。本文综述了纳米颗粒的有效性，以及纳米颗粒可能的作用方式。除纳米颗粒外，还讨论了细胞穿透肽（CPP）介导的药物进入皮肤以及CPP衍生的药物进入皮肤的可能机制。最后，讨论了聚苯乙烯修饰的纳米载体进入皮肤的有效性和可能的机制。
Topical or transdermal drug delivery is challenging because the skin acts as a natural and protective barrier. Therefore, several methods have been examined to increase the permeation of therapeutic molecules into and through the skin. One approach is to use the nanoparticulate delivery system. Starting with liposomes and other vesicular systems, several other types of nanosized drug carriers have been developed such as solid lipid nanoparticles, nanostructured lipid carriers, polymer-based nanoparticles and magnetic nanoparticles for dermatological applications. This review article discusses how different particulate systems can interact and penetrate into the skin barrier. In this review, the effectiveness of nanoparticles, as well as possible mode of actions of nanoparticles, is presented. In addition to nanoparticles, cell-penetrating peptide (CPP)-mediated drug delivery into the skin and the possible mechanism of CPP-derived delivery into the skin is discussed. Lastly, the effectiveness and possible mechanism of CPP-modified nanocarriers into the skin are addressed.
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影响因子：
6.5
作者：
Jung, Sascha;Otberg, Nina;Lademann, Juergen
通讯作者：
Lademann, Juergen
影响因子：
10.8
作者：
Carrer, Dolores C.;Vermehren, Charlotte;Bagatolli, Luis A.
通讯作者：
Bagatolli, Luis A.
影响因子：
7.4
作者：
Jin, LH;Bahn, JH;Choi, SY
通讯作者：
Choi, SY
DOI：
10.1159/000056393
发表时间：
2001-01-01
期刊：
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
影响因子：
--
作者：
Hadgraft, J
通讯作者：
Hadgraft, J
影响因子：
6.5
作者：
Honeywell-Nguyen, PL;Gooris, GS;Bouwstra, JA
通讯作者：
Bouwstra, JA