Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial.
Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial.
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病毒检测及其与流感样性疾病期间的症状相关联，在接受随机对照疫苗试验的健康成年人样本中。
DOI：
10.1111/j.1750-2659.2012.00395.x
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发表时间：
2013-05
影响因子：
4.4
通讯作者：
McVernon J
中科院分区：
文献类型：
--
作者：
Howard PF;McCaw JM;Richmond PC;Nissen M;Sloots T;Lambert SB;Lai M;Greenberg M;Nolan T;McVernon J
背景病毒性呼吸道感染与显著的发病率和死亡率相关。 最近描述了许多新的病原体。 目的我们在一个基于人群的流感样疾病（ILI）健康成人样本中寻找呼吸道病毒。 我们研究了宿主和时空与病毒分离的关联，以及宿主、时空和病毒与自我报告症状的关联。 患者/方法我们从参加流感疫苗有效性试验的健康成人人群中招募了586名经历651次疾病发作的参与者。 在ILI评估访视时，采集呼吸道拭子，并使用聚合酶链反应（PCR）检测组合进行病毒检测。参与者还完成了一份问卷，详细介绍了他们在336次发作中的临床过程。 结果在643份样本中，44%的样本被鉴定出病毒。 其中一半是小核糖核酸病毒，其次是流感病毒和冠状病毒。流感患者接受免疫接种的可能性显著低于参考（病毒阴性）人群（OR = 0.52（0.31，0.87）P = 0.01）。 流感患者报告的平均症状评分（95% CI）显著高于所有其他发作[流感：10.2（9.4，10.9）;其他：7.4（7.2，7.7）;差异（95% CI）：2.5（1.5，3.5）; P <0.001]。 在一项仅限于流感阳性病例的分析中，接种疫苗后症状评分未减弱。 结论：我们的研究结果表明，更多的症状是由个人提出的流感证实ILI与其他因素相比，导致ILI。 虽然流感疫苗接种降低了流感病毒检测的概率，但流感阳性ILI的症状评分并未减弱。
Background Viral respiratory infections are associated with significant morbidity and mortality. Many new aetiological agents have been described recently. Objectives We looked for respiratory viruses in a population‐based sample of healthy adults with influenza‐like illness (ILI). We investigated host and spatio‐temporal associations with virus isolation and host, spatio‐temporal and virus associations with self‐reported symptoms. Patients/Methods We recruited 586 participants experiencing 651 illness episodes from a population of healthy adults enrolled in an influenza vaccine effectiveness trial. At ILI assessment visits, a respiratory swab was collected and tested for viruses using a combination of polymerase chain reaction (PCR) assays. Participants also completed a questionnaire detailing their clinical course in 336 episodes. Results Of 643 samples analysed, a virus was identified in 44%. Half were picornaviruses, with influenza and coronaviruses the next most common. Individuals with influenza were significantly less likely to have been immunised than the reference (virus negative) population (OR = 0·52 (0·31, 0·87) P = 0·01). The mean symptom score (95% CI) reported by individuals with influenza was significantly higher than in all other episodes [Influenza: 10·2 (9·4, 10·9); Other: 7·4 (7·2, 7·7); Difference (95% CI): 2·5 (1·5, 3·5); P < 0·001]. In an analysis restricted to influenza‐positive cases, the symptom score was not attenuated by vaccination. Conclusions Our findings indicate that a greater number of symptoms are displayed by individuals presenting with influenza confirmed ILI compared with other agents that cause ILI. While influenza vaccination reduced the probability of influenza virus detection, symptom score for influenza‐positive ILI was not attenuated.
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影响因子：
4.7
作者：
Anestad, Gabriel;Nordbo, Svein Arne
通讯作者：
Nordbo, Svein Arne
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B
香港COPD急性加重的病毒病因。
影响因子：
9.6
作者：
Ko FW;Ip M;Chan PK;Chan MC;To KW;Ng SS;Chau SS;Tang JW;Hui DS
通讯作者：
Hui DS
影响因子：
5.5
作者：
Girard MP;Cherian T;Pervikov Y;Kieny MP
通讯作者：
Kieny MP
影响因子：
1.7
作者：
Lambert, SB;O'Grady, KF;Nolan, TM
通讯作者：
Nolan, TM