Is There a Role for Basophils in Cancer?
Is There a Role for Basophils in Cancer?
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DOI：
10.3389/fimmu.2020.02103
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发表时间：
2020
影响因子：
7.3
通讯作者：
Varricchi G
中科院分区：
文献类型：
--
作者：
Marone G;Schroeder JT;Mattei F;Loffredo S;Gambardella AR;Poto R;de Paulis A;Schiavoni G;Varricchi G
Paul Ehrlich 于 140 多年前在人类外周血中发现了嗜碱性粒细胞。人类嗜碱性粒细胞占外周血白细胞的比例<1%。在过去的几十年里，在小鼠、豚鼠、兔子和猴子中也发现了嗜碱性粒细胞。人类和小鼠嗜碱性粒细胞之间有许多相似之处，但也存在一些免疫学差异。目前有几种小鼠品系具有严重的组成性或诱导性嗜碱性粒细胞缺乏症，可用于证明这些细胞在体内具有特定的作用。然而，这些小鼠中没有一只完全没有嗜碱性粒细胞。因此，这些发现与人类的相关性仍有待确定。一段时间以来，人们已经知道嗜碱性粒细胞有迁移到炎症部位的倾向。最近的观察表明，组织驻留嗜碱性粒细胞有助于肺部发育并局部促进巨噬细胞的 M2 极化。此外，越来越多的证据表明，肺内嗜碱性粒细胞表现出与循环嗜碱性粒细胞不同的特定表型。激活的人和小鼠嗜碱性粒细胞合成有限且独特的细胞因子。人类嗜碱性粒细胞产生多种典型（例如 VEGF、血管生成素 1）和非典型（即半胱氨酰白三烯 C4）血管生成因子。激活的人类和小鼠嗜碱性粒细胞释放细胞外 DNA 陷阱，可能对癌症产生多种影响。 JAK2V617F 阳性真性红细胞增多症患者中已证实嗜碱性粒细胞高反应性。嗜碱性粒细胞存在于人类肺腺癌和胰腺癌的免疫环境中，可以促进炎症驱动的皮肤肿瘤生长。迄今为止，使用不同的嗜碱性粒细胞缺陷小鼠模型进行的少数研究提供了有关这些细胞在肿瘤发生中的作用的信息性结果。在我们揭开嗜碱性粒细胞在人类和实验癌症中迄今神秘的作用之前，还有更多的事情有待发现。
Basophils were identified in human peripheral blood by Paul Ehrlich over 140 years ago. Human basophils represent <1% of peripheral blood leukocytes. During the last decades, basophils have been described also in mice, guinea pigs, rabbits, and monkeys. There are many similarities, but also several immunological differences between human and mouse basophils. There are currently several strains of mice with profound constitutive or inducible basophil deficiency useful to prove that these cells have specific roles in vivo. However, none of these mice are solely and completely devoid of all basophils. Therefore, the relevance of these findings to humans remains to be established. It has been known for some time that basophils have the propensity to migrate into the site of inflammation. Recent observations indicate that tissue resident basophils contribute to lung development and locally promote M2 polarization of macrophages. Moreover, there is increasing evidence that lung-resident basophils exhibit a specific phenotype, different from circulating basophils. Activated human and mouse basophils synthesize restricted and distinct profiles of cytokines. Human basophils produce several canonical (e.g., VEGFs, angiopoietin 1) and non-canonical (i.e., cysteinyl leukotriene C4) angiogenic factors. Activated human and mouse basophils release extracellular DNA traps that may have multiple effects in cancer. Hyperresponsiveness of basophils has been demonstrated in patients with JAK2V617F-positive polycythemia vera. Basophils are present in the immune landscape of human lung adenocarcinoma and pancreatic cancer and can promote inflammation-driven skin tumor growth. The few studies conducted thus far using different models of basophil-deficient mice have provided informative results on the roles of these cells in tumorigenesis. Much more remains to be discovered before we unravel the hitherto mysterious roles of basophils in human and experimental cancers.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
30.5
作者：
Crawford G;Hayes MD;Seoane RC;Ward S;Dalessandri T;Lai C;Healy E;Kipling D;Proby C;Moyes C;Green K;Best K;Haniffa M;Botto M;Dunn-Walters D;Strid J
通讯作者：
Strid J
影响因子：
4.6
作者：
Colazzo F;Gelosa P;Tremoli E;Sironi L;Castiglioni L
通讯作者：
Castiglioni L
影响因子：
24.8
作者：
Bankova LG;Dwyer DF;Yoshimoto E;Ualiyeva S;McGinty JW;Raff H;von Moltke J;Kanaoka Y;Frank Austen K;Barrett NA
通讯作者：
Barrett NA
DOI：
10.4049/jimmunol.1201865
发表时间：
2012-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Barrett NA;Fernandez JM;Maekawa A;Xing W;Li L;Parsons MW;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y