Varicella‐zoster infection in pediatric solid‐organ transplant recipients:A hospital‐based study in the prevaricella vaccine era
Varicella‐zoster infection in pediatric solid‐organ transplant recipients:A hospital‐based study in the prevaricella vaccine era
复制标题
儿童实体器官移植受者的水痘带状疱疹感染：水痘疫苗时代的一项基于医院的研究
作者：
A. Pandya;S. Wasfy;D. Hébert;U. Allen
翻译后摘要：我们回顾了58例水痘带状疱疹感染，发生在1988年和1998年之间的47个儿科实体器官移植受者。水痘带状疱疹感染患者入院时的中位年龄为8.0岁（范围1-17岁）。 移植（Tx）和水痘带状疱疹病毒（VZV）感染之间的中位间隔为1.6年（范围0.06-9.3年）。 水痘感染的发生率为每7例移植受者中有1例。在58例VZV感染病例中，53%为水痘，47%为带状疱疹。在31例水痘感染病例中，17例在接受水痘带状疱疹免疫球蛋白（VZIG）治疗后仍发生水痘感染。然而，这种疾病一般是轻度的，只有两名患者发生了严重的疾病。1例患者（1.7%）死于细菌性败血症。VZV感染与特异性免疫抑制剂无明显关系。排异反应的发生与带状疱疹的发生比与水痘感染的发生更可能存在时间上的相关性（p = 0.02）。 所产生的数据提供了有用的背景信息，在我们的人口在水痘疫苗时代。
Abstract: We reviewed 58 cases of varicella‐zoster infection that occurred between 1988 and 1998 in 47 pediatric solid‐organ transplant recipients. The median age of patients at the time of admission with varicella‐zoster infection was 8.0 yr (range 1–17 yr). The median interval between transplantation (Tx) and varicella‐zoster virus (VZV) infection was 1.6 yr (range 0.06–9.3 yr). Varicella infection occurred at a rate of one case for every seven transplant recipients. Among the 58 cases of VZV infection, 53% were varicella while 47% were herpes‐zoster. Varicella infection occurred despite treatment with varicella‐zoster immune globulin (VZIG) in 17 of 31 cases of varicella infection. However, the disease was generally mild with severe disease occurring in only two patients. One patient (1.7%) died as a result of bacterial sepsis. There was no significant relationship between VZV infection and specific immune suppressants. Episodes of rejection were more likely to be temporally associated with the occurence of herpes zoster than with varicella infection (p = 0.02). The data generated provide useful background information in our population in the prevaricella vaccine era.
接种水痘减毒活疫苗的白血病儿童对水痘免疫力的持续性。
DOI：
10.1056/nejm198904063201403
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gershon,AA;Steinberg,SP
通讯作者：
Steinberg,SP
水痘减毒活疫苗用于免疫功能低下的儿童和成人。
影响因子：
8
作者：
Gershon,AA;Steinberg,SP;Gelb,L
通讯作者：
Gelb,L
影响因子：
6.4
作者：
BREINIG, MK;ZITELLI, B;HO, M
通讯作者：
HO, M