Survival changes in Patients with Synovial Sarcoma, 1983-2012.
Survival changes in Patients with Synovial Sarcoma, 1983-2012.
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1983 年至 2012 年滑膜肉瘤患者的生存变化
DOI：
10.7150/jca.17349
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发表时间：
2017
影响因子：
3.9
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Wang S;Song R;Sun T;Hou B;Hong G;Mallampati S;Sun H;Zhou X;Zhou C;Zhang H;Cheng Z;Li J;Ma H;Sun H
背景：滑膜肉瘤（SyS）是一种罕见的恶性肿瘤，通常侵犯四肢，主要发生在青少年。尚未有基于大量人群的SyS发病率和生存率研究的报道。研究方法：为了评估三十年来SyS发病率和生存率的变化，我们从监测，流行病学和最终结果（SEER）数据库中访问了1983年至2012年（1983-1992年，1993-2002年和2003-2012年）每个十年的SyS病例数据。通过Kaplan-Meier曲线比较不同年代、年龄组、性别、种族、病理类型、部位、分期和社会经济状况（SES）之间的生存差异。结果：我们在1983年至2012年期间在18个SEER登记区域发现了2，070例SyS病例。结果表明，在总人口和大部分年龄组中，SyS的发病率从0.906/100万上升到1.348/100万和1.548/100万，发病高峰年龄在15-29岁。SyS患者的5年生存率分别为69.4%、61.1%和60.5%（p > 0.05），但30年来生存率无明显改善。有趣的是，随着时间的推移，观察到种族，性别，病理类型和各种SES之间的生存差距不断扩大，p值不断缩小。结论：这项研究表明，在大样本中，30年来发病率不断增加，生存率没有改善，这表明进一步发展诊断，提高医疗保健提供者对SyS的认识并导致新治疗方法的开发的紧迫性。
Background: Synovial sarcoma (SyS) is a rare malignancy that typically invades the extremities and occurs predominantly in adolescents. Studies on incidence and survival in SyS that were based on a large population had not been reported yet. Methods: To evaluate changes in incidence and survival in SyS over three decades, we accessed data on SyS cases in each decade between 1983 and 2012 (1983-1992, 1993-2002, and 2003-2012) from the Surveillance, Epidemiology, and End Results (SEER) database. The survival difference between decades, age groups, sexes, race, pathologic types, sites, stages and socioeconomic status (SES) over three decades were accessed by comparing Kaplan-Meier curves. Results: We located 2,070 SyS cases in 18 SEER registry regions between 1983 and 2012. Our study demonstrated that the incidence of SyS per 1,000,000 continued to increase from 0.906 to 1.348 to 1.548 in the total population and in most age groups and that the age of incidence peak was 15-29 years in three decades. But, the survival of patients with SyS did not significantly improve throughout the three decades, with 5-year survival rates of 69.4%, 61.1% and 60.5% respectively (p > 0.05). Interestingly, the widening survival gaps among races, sexes, pathological types and various SES over time were observed, with narrowing p values. Conclusions: This study demonstrated the increasing incidence and unimproved survival rates across three decades in a large sample, indicating the urgency for further development of diagnosis, improving health care providers' awareness of SyS and lead to the development of novel treatments.
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影响因子：
--
作者：
Radhakrishnan V;Dhanushkodi M;Narayanswamy K;Raja A;Sundersingh S;Sagar T
通讯作者：
Sagar T
影响因子：
2.5
作者：
Teng, Hao-Wei;Wang, Hsei-Wei;Yen, Chueh-Chuan
通讯作者：
Yen, Chueh-Chuan
影响因子：
45.3
作者：
Robbins, Paul F.;Morgan, Richard A.;Rosenberg, Steven A.
通讯作者：
Rosenberg, Steven A.
胰腺癌患者的生存率提高了十年：SEER 数据库的时期分析，1981 年至 2010 年
影响因子：
4.6
作者：
Sun H;Ma H;Hong G;Sun H;Wang J
通讯作者：
Wang J
影响因子：
5.7
作者：
Wakamatsu T;Naka N;Sasagawa S;Tanaka T;Takenaka S;Araki N;Ueda T;Nishizawa Y;Yoshikawa H;Itoh K
通讯作者：
Itoh K