Prospective study of zinc intake and risk of type 2 diabetes in women.
Prospective study of zinc intake and risk of type 2 diabetes in women.
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DOI：
10.2337/dc08-1913
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发表时间：
2009-04
期刊：
影响因子：
16.2
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Sun Q;van Dam RM;Willett WC;Hu FB
这项研究的目的是调查美国妇女锌的摄入量与2型糖尿病风险的关系。在护士健康研究中，使用1980年至2002年期间经过验证的食物频率问卷对82，297名年龄在1980年基线时33-60岁的女性进行了锌和其他营养素的饮食摄入量评估和更新，并随访至2004年。在24年的随访中，确定了6，030例2型糖尿病事件。在调整生活方式和饮食危险因素后，2型糖尿病的相对危险度（RR）（95%CI）比较最高和最低五分位数分别为0.90（0.82-0.99）（Ptrend = 0.04）总锌摄入量和0.92（0.84-1.00）（Ptrend = 0.009）从食物中摄入锌。我们进一步发现饮食锌血红素铁比例呈负相关。在对协变量进行多变量调整后，该比值的五分位数的RR（95% CI）分别为1.0（参考）、0.93（0.86-1.01）、0.86（0.79-0.94）、0.82（0.75-0.90）和0.72（0.66-0.80）（P趋势< 0.0001）。较高的锌摄入量可能与女性患2型糖尿病的风险略低有关。需要更多的研究来证实这种关联并探索潜在的机制。
The aim of this study is to investigate the intake of zinc in relation to risk of type 2 diabetes in U.S. women. Dietary intakes of zinc and other nutrients were assessed and updated using a validated food frequency questionnaire from 1980 to 2002 among 82,297 women who were aged 33–60 years at baseline in 1980 and followed up to 2004 in the Nurses' Health Study. During the 24 years of follow-up, 6,030 incident cases of type 2 diabetes were ascertained. After adjustment of lifestyle and dietary risk factors, the relative risks (RRs) (95% CI) of type 2 diabetes comparing the highest with the lowest quintiles were 0.90 (0.82–0.99) (Ptrend = 0.04) for total zinc intake and 0.92 (0.84–1.00) (Ptrend = 0.009) for dietary zinc intake from food sources, respectively. We further found an inverse association for dietary zinc to heme iron ratio. After multivariate adjustment of covariates, the RRs (95% CI) across quintiles of this ratio were 1.0 (reference), 0.93 (0.86–1.01), 0.86 (0.79–0.94), 0.82 (0.75–0.90), and 0.72 (0.66–0.80), respectively (Ptrend < 0.0001). Higher zinc intake may be associated with a slightly lower risk of type 2 diabetes in women. More studies are warranted to confirm this association and to explore potential mechanisms.
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影响因子：
3.9
作者：
Marreiro, Dilina do Nascimento;Geloneze, Bruno;Franciscato Cozzolino, Silvia Maria
通讯作者：
Franciscato Cozzolino, Silvia Maria
影响因子：
4.2
作者：
SOLOMONS, NW
通讯作者：
SOLOMONS, NW
影响因子：
3.2
作者：
Simon, SF;Taylor, CG
通讯作者：
Taylor, CG
影响因子：
5
作者：
WILLETT, WC;SAMPSON, L;SPEIZER, FE
通讯作者：
SPEIZER, FE
影响因子：
7.7
作者：
BEGINHEICK, N;DALPESCOTT, M;HEICK, HMC
通讯作者：
HEICK, HMC