Motor imagery in normal subjects and in asymmetrical Parkinson’s disease
Motor imagery in normal subjects and in asymmetrical Parkinson’s disease
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正常受试者和不对称帕金森病的运动想象
DOI：
10.1212/wnl.55.7.996
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发表时间：
2000
期刊：
影响因子：
9.9
通讯作者：
E. Broussolle
中科院分区：
文献类型：
--
作者：
S. Thobois;Peter Ford Dominey;J. Decety;P. Pollak;M. Grégoire;P. D. Le Bars;E. Broussolle
目的：应用PET和H215O研究帕金森病（PD）患者运动想象时的脑激活异常。确定运动想象激活模式是否依赖于完成任务所用的手。背景：先前的研究表明，运动迟缓与运动想象的缓慢有关。研究方法：PET研究在8名主要为右侧运动不能的PD患者和8名年龄匹配的对照受试者中进行，所有受试者均为右利手。局部脑血流量的PET和H215O测量，而受试者想象一个预定的单手外部提示顺序运动与操纵杆与左手或右手，并在休息条件。结果如下：在正常受试者中，前额叶皮层，补充运动区（SMA），上级顶叶，额下回，小脑被激活时，无论是用左手或右手的运动想象。仅当用右手（优势手）想象任务时才注意到外侧初级运动皮层的激活，而仅在用左手想象时才观察到背外侧前额叶皮层的激活。在PD患者中，右手（“运动不能”）的运动想象的特征是对侧初级感觉运动皮层和小脑缺乏激活，SMA持续激活，以及上级顶叶皮层的双侧激活。左手（“非运动不能”）的运动想象也异常，与对照组相比，SMA缺乏激活。结论：在主要为右侧运动不能的PD患者中，运动想象过程中的大脑激活是异常的，甚至可能出现在受影响较小的手。在正常的受试者中，运动想象过程中的大脑激活取决于想象运动中使用的手。
Objective: To investigate, using PET and H215O, brain activation abnormalities of patients with PD during motor imagery. To determine whether motor imagery activation patterns depend on the hand used to complete the task. Background: Previous work in PD has shown that bradykinesia is associated with slowness of motor imagery. Methods: The PET study was performed in eight patients with PD with predominantly right-sided akinesia, and in eight age-matched control subjects, all right-handed. Regional cerebral blood flow was measured by PET and H215O while subjects imagined a predetermined unimanual externally cued sequential movement with a joystick with either the left or the right hand, and during a rest condition. Results: In normal subjects, the prefrontal cortex, supplementary motor area (SMA), superior parietal lobe, inferior frontal gyrus, and cerebellum were activated during motor imagery with either the left or the right hand. Contralateral primary motor cortex activation was noted only when the task was imagined with the right (dominant) hand, whereas activation of the dorsolateral prefrontal cortex was observed only during imagery with the left hand. In patients with PD, motor imagery with the right (“akinetic”) hand was characterized by lack of activation of the contralateral primary sensorimotor cortex and the cerebellum, persistent activation of the SMA, and bilateral activation of the superior parietal cortex. Motor imagery with the left (“non-akinetic”) hand was also abnormal, with lack of activation of the SMA compared with controls. Conclusions: In patients with PD with predominantly right-sided akinesia, brain activation during motor imagery is abnormal and may appear even with the less affected hand. In normal subjects, brain activation during motor imagery depends on the hand used in the imagined movement.
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
DOI：
10.1164/ajrccm/147.4.887
发表时间：
1993-04-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
KRIBBS, NB;PACK, AI;DINGES, DF
通讯作者：
DINGES, DF