Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after HIV exposures--worldwide, 1997-2000.
Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after HIV exposures--worldwide, 1997-2000.
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1997 年至 2000 年，全球范围内，艾滋病毒暴露后使用奈韦拉平治疗方案进行暴露后预防的严重不良事件。
DOI：
--
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
S. Kukich
中科院分区：
文献类型：
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作者：
S. Kukich
2000年9月，在职业性人类免疫缺陷病毒（HIV）暴露后服用奈韦拉平（NVP）进行暴露后预防（PEP）的卫生保健工作者中报告了两例危及生命的肝毒性。在一个病例中，一名43岁的女性医护人员在针刺伤后服用NVP、齐多夫定和拉米夫定作为PEP时发生暴发性肝炎和终末期肝功能衰竭，需要进行肝移植（1）。在第二个病例中，一名38岁的男性医生在粘膜暴露后服用NVP、齐多夫定和拉米夫定作为PEP时因危及生命的暴发性肝炎住院。为了表征NVP相关PEP毒性，CDC和美国食品药品监督管理局（FDA）审查了FDA收到的关于服用NVP治疗PEP的患者严重不良事件的MedWatch报告（图1）。本报告总结了该分析的结果，并指出健康人接受缩短的4周NVP方案治疗PEP有发生严重不良事件的风险。临床医生应使用推荐的PEP指南和剂量说明，以降低严重不良事件的风险。
In September 2000, two instances of life-threatening hepatotoxicity were reported in health-care workers taking nevirapine (NVP) for postexposure prophylaxis (PEP) after occupational human immunodeficiency virus (HIV) exposure. In one case, a 43-year-old female health-care worker required liver transplantation after developing fulminant hepatitis and end-stage hepatic failure while taking NVP, zidovudine, and lamivudine as PEP following a needlestick injury (1). In the second case, a 38-year-old male physician was hospitalized with life-threatening fulminant hepatitis while taking NVP, zidovudine, and lamivudine as PEP following a mucous membrane exposure. To characterize NVP-associated PEP toxicity, CDC and the Food and Drug Administration (FDA) reviewed MedWatch reports of serious adverse events in persons taking NVP for PEP received by FDA (Figure 1). This report summarizes the results of that analysis and indicates that healthy persons taking abbreviated 4-week NVP regimens for PEP are at risk for serious adverse events. Clinicians should use recommended PEP guidelines and dosing instructions to reduce the risk for serious adverse events.
孕期母亲吸毒与母亲艾滋病毒培养阳性和围产期艾滋病毒传播之间的关系。
DOI：
10.1097/00002030-199603000-00006
发表时间：
1996
期刊：
AIDS (London, England)
影响因子：
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作者：
Rodriguez,EM;Mofenson,LM;Chang,BH;Rich,KC;Fowler,MG;Smeriglio,V;Landesman,S;Fox,HE;Diaz,C;Green,K;Hanson,IC
通讯作者：
Hanson,IC