Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease.
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease.
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DOI：
10.1373/clinchem.2016.259085
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发表时间：
2017-03
影响因子：
9.3
通讯作者：
Wein MN
中科院分区：
文献类型：
--
作者：
Greenblatt MB;Tsai JN;Wein MN
骨代谢紊乱，尤其是骨质疏松症，非常普遍，易发生骨折，导致患者高发病率和高死亡率。骨代谢缺陷的诊断和监测可能是一个主要的挑战，因为这些疾病在很大程度上是无症状的，骨量的放射学测量对骨生理的变化反应迟缓。骨转换标志物(BTM)是成骨细胞或破骨细胞在骨重建过程中释放的一系列蛋白质或蛋白质衍生生物标志物。BTMS可以提供关于骨折风险的预后信息，补充骨量的放射测量，但使用BTMS进行测试必须考虑到大量的分析前因素和影响BTM水平的共病临床条件。BTM对骨生理变化的反应迅速，因此，它们在确定患者对骨质疏松症治疗的反应和依从性方面具有实用价值。BTM对于骨代谢紊乱的诊断和治疗监测是一种有用的辅助手段，但它们的使用必须受到其临床应用的已知局限性和分析前变量复杂解释的限制。
Disorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality. Diagnosis and monitoring of bone metabolic defects can present a major challenge as these disorders are largely asymptomatic and radiographic measures of bone mass respond slowly to changes in bone physiology. Bone turnover markers (BTMs) are a series of protein or protein derivative biomarkers released during bone remodeling by osteoblasts or osteoclasts. BTMs can offer prognostic information on fracture risk that supplements radiographic measures of bone mass, but testing using BTMs has to take into account the large number of preanalytic factors and comorbid clinical conditions influencing BTM levels. BTMs respond rapidly to changes in bone physiology, therefore, they have utility in determining patient response to and compliance with therapies for osteoporosis. BTMs are a useful adjunct for the diagnosis and therapeutic monitoring of bone metabolic disorders, but their use has to be tempered by the known limitations in their clinical utility and preanalytic variables complicating interpretation.
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影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
6.2
作者：
Eastell, R;Barton, I;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
4
作者：
Fall, PM;Kennedy, D;Raisz, LG
通讯作者：
Raisz, LG
影响因子：
4.1
作者：
Apone, S;Lee, MY;Eyre, DR
通讯作者：
Eyre, DR
影响因子：
4
作者：
Blumsohn, A.;Marin, F.;Nickelsen, T.;Brixen, K.;Sigurdsson, G.;Gonzalez de la Vera, J.;Boonen, S.;Liu-Leage, S.;Barker, C.;Eastell, R.
通讯作者：
Eastell, R.