Expressions and significances of CTSL, the target of COVID-19 on GBM.
Expressions and significances of CTSL, the target of COVID-19 on GBM.
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CTSL的表达和意义，这是Covid-19在GBM上的靶标。
DOI：
10.1007/s00432-021-03843-9
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发表时间：
2022-03
影响因子：
3.6
通讯作者：
Pan Y
中科院分区：
文献类型：
--
作者：
Dong Q;Li Q;Duan L;Wang H;Yan Y;Yin H;Niu L;Zhang H;Wang B;Yuan G;Pan Y
组织蛋白酶L（Cathepsin L，CTSL）是一种与SARS病毒进入细胞相关的蛋白酶，在病毒进入细胞并感染细胞过程中起着关键作用。我们研究了多形性胶质母细胞瘤（GBM）患者CTSL表达水平与总生存期之间的关系，以更好地了解GBM患者新型冠状病毒感染的可能途径和风险。使用TCGA和CGGA数据库分析GBM中CTSL的表达水平。通过TIMER数据库分析CTSL与免疫浸润水平的关系。测试了CTSL抑制剂对GBM生物活性的影响。结果显示，GBM组织中CTSL表达水平高于正常脑组织，这与GBM患者的生存率显著降低有关。CTSL的表达水平与GBM的纯度、B细胞和CD 8 + T细胞呈负相关。CTSL抑制剂显著降低生长并诱导线粒体凋亡。CTSL是一个独立的预后因子，可作为GBM治疗的靶点。在线版本包含补充材料，可通过10.1007/s 00432 -021-03843-9获得。
Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiforme (GBM) patients, to better understand the possible route and risks of new coronavirus infection for patients with GBM. The expression level of CTSL in GBM was analyzed using TCGA and CGGA databases. The relationship between CTSL and immune infiltration levels was analyzed by means of the TIMER database. The impact of CTSL inhibitors on GBM biological activity was tested. The findings revealed that GBM tissues had higher CTSL expression levels than that of normal brain tissues, which was associated with a significantly lower survival rate in GBM patients. Meanwhile, the expression level of CTSL negatively correlated with purity, B cell and CD8+ T cell in GBM. CTSL inhibitor significantly reduced growth and induced mitochondrial apoptosis. According to the findings, CTSL acts as an independent prognostic factor and can be considered as promising therapeutic target for GBM. The online version contains supplementary material available at 10.1007/s00432-021-03843-9.
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影响因子：
56.9
作者：
Nakagawa, T;Roth, W;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
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作者：
Yu S;Yu Y;Zhang W;Yuan W;Zhao N;Li Q;Cui Y;Wang Y;Li W;Sun Y;Liu T
通讯作者：
Liu T
影响因子：
4
作者：
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通讯作者：
Siemann, Dietmar W.
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
影响因子：
33.5
作者：
Zhou, Yadi;Hou, Yuan;Cheng, Feixiong
通讯作者：
Cheng, Feixiong