Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment.
Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment.
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DOI：
10.1155/2015/854307
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Bao Y
中科院分区：
文献类型：
--
作者：
Guo Q;Lin J;Liu R;Gao Y;He S;Xu X;Hua B;Li C;Hou W;Zheng H;Bao Y
西黄丸（XH）是一种补充和替代药物，自18世纪以来一直用于中医治疗肿瘤。XH对非霍奇金淋巴瘤、乳腺癌、胃癌、肝癌、骨转移等有临床疗效。XH还能抑制肿瘤细胞和肿瘤干细胞的生长，阻止肿瘤侵袭和血管生成，调节肿瘤微环境。XH由乳香、墨瑶、麝香、牛黄组成。在这些成分中发现的一些化合物具有多种抗肿瘤作用，并可能与其他成分协同作用。本文就XH的临床应用、分子机制及其化学成分进行综述。本文综述将为肿瘤治疗和补充替代医学基础研究提供潜在的新策略和新视角。
Xihuang pill (XH) is a complementary and alternative medicine that has been used in traditional Chinese medicine (TCM) for the treatment of tumors since the 18th century. XH has clinical effects on non-Hodgkin lymphoma, breast cancer, gastric cancer, liver cancer, and bone metastasis. XH can also inhibit the growth of tumor cells and cancer stem cells, prevent tumor invasion and angiogenesis, and regulate the tumor microenvironment. XH is composed of Ru Xiang (olibanum), Mo Yao (Commiphora myrrha), She Xiang (Moschus), and Niu Huang (Calculus bovis). Some of the compounds found in these ingredients exert multiple antitumor effects and may synergize with the other ingredients. We aimed to summarize the clinical applications and molecular mechanisms of XH and its chemical composition. This review will provide potential new strategies and alternative perspectives for tumor treatments and basic research into complementary and alternative medicine.
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