DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia
DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia
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成人急性淋巴细胞白血病DNMT3A突变分析
DOI：
10.1007/s11596-015-1434-1
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发表时间：
2015
影响因子：
--
通讯作者：
Xiao, Min
中科院分区：
文献类型：
--
作者：
Yang, Li;Ding, Xiao-yi;Zhou, Jian-feng;Xiao, Min
DNA甲基转移酶3A （DNMT3A）突变最近被确定为急性髓性白血病（AML）患者的独立危险因素。然而，关于其对急性淋巴细胞白血病（ALL）患者的发病率和后续影响的报道很少，特别是在中国人群中。在这项研究中，我们研究了57例中国成人ALL患者DNMT3A突变的发生率和预后意义。共有3例（5.3%）T-ALL患者存在DNMT3A R882H突变，显著高于B-ALL亚型（P=0.048）。40 ~ 60岁患者突变率高于其他年龄组（P=0.042）。DNMT3A突变患者的总生存期（OS）比野生型患者短。我们的研究表明，中国ALL患者可能发生DNMT3A突变，对其预后产生负面影响。这些发现可能有助于中国ALL患者的风险分层和治疗选择。
DNA methyl-transferase 3A (DNMT3A) mutation has recently been identified as an independent risk factor for patients with acute myeloid leukemia (AML). However, reports are scanty on its rate and subsequent impact on patients with acute lymphoblastic leukemia (ALL), especially in Chinese population. In this study, we investigated the incidence and prognostic implication of DNMT3A mutation in 57 Chinese adult ALL patients. A total of 3 (5.3%) T-ALL cases were found to have the DNMT3A R882H mutation, which was significantly greater than that found in B-ALL subtype (P=0.048). The patients aged between 40 and 60 years old had higher mutation rate than other age groups (P=0.042). Patients with DNMT3A mutation had shorter overall survival (OS) than their wild-type counterparts. Our study demonstrated that Chinese ALL patients might develop DNMT3A mutation, which exerts a negative impact on their prognosis. These findings might help in risk stratification and treatment choice for Chinese ALL patients.
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影响因子：
2.9
作者：
Iacobucci, Ilaria;Papayannidis, Cristina;Lonetti, Annalisa;Ferrari, Anna;Baccarani, Michele;Martinelli, Giovanni
通讯作者：
Martinelli, Giovanni
DOI：
10.18103/imr.v2i9.172
发表时间：
2016
期刊：
Internal Medicine Review
影响因子：
--
作者：
O. Blau
通讯作者：
O. Blau
影响因子：
6.5
作者：
N. Rao;C. Butcher;I. Lewis;D. Ross;J. Melo;H. Scott;P. Bardy;R. D’Andrea
通讯作者：
N. Rao;C. Butcher;I. Lewis;D. Ross;J. Melo;H. Scott;P. Bardy;R. D’Andrea
影响因子：
4
作者：
N. Rodríguez-Osorio;Hongfeng Wang;Jennifer Rupinski;S. Bridges;E. Memili
通讯作者：
N. Rodríguez-Osorio;Hongfeng Wang;Jennifer Rupinski;S. Bridges;E. Memili
影响因子：
8.3
作者：
J. Turek-Plewa;P. Jagodziński
通讯作者：
J. Turek-Plewa;P. Jagodziński