Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs.
Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs.
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DOI：
10.1016/j.fob.2014.01.010
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发表时间：
2014
期刊：
影响因子：
2.6
通讯作者：
José MV
中科院分区：
文献类型：
--
作者：
Farias ST;Rêgo TG;José MV
我们验证了肽转移酶中心(PTC)起源于原tRNAs的说法。重建了原tRNA的祖先。将它们的序列与几种生物的PTC序列进行了比较。我们得出结论，原tRNA的融合可能导致了PTC的产生。我们检验了Tamura(2011)[3]的假设，即tRNA分子起源于核糖体，特别是23S核糖体RNA的肽基转移酶中心(PTC)。我们从所有类型的tRNA中重建了祖先序列，并将它们的序列与目前来自不同生物的23S核糖体RNA的PTC进行了比较。我们构建了一个原始tRNAs序列，该序列与PTC的催化位点有50.53%的同源性。我们的结论是，肽转移酶中心确实是由原始tRNA的祖先序列融合而来。
We tested the proposal that the Peptidyl Transferase Center (PTC) originated from proto-tRNAs. Proto-tRNA ancestors were reconstructed. Their sequences were compared to the sequences of the PTC from several organisms. We conclude that fusions of proto-tRNAs may have given rise to the PTC. We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA.
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DOI：
10.1107/s0907444913004745
发表时间：
2013-06-01
影响因子：
2.2
作者：
Gabdulkhakov, Azat;Nikonov, Stanislav;Garber, Maria
通讯作者：
Garber, Maria
影响因子：
56.9
作者：
Selmer, Maria;Dunham, Christine M.;Ramakrishnan, V.
通讯作者：
Ramakrishnan, V.
影响因子：
7.2
作者：
Fox, George E.
通讯作者：
Fox, George E.
影响因子：
2
作者：
Kua, Jeremy;Bada, Jeffrey L.
通讯作者：
Bada, Jeffrey L.
影响因子：
56.9
作者：
Nissen, P;Hansen, J;Steitz, TA
通讯作者：
Steitz, TA