SARS-CoV-2 Cumulative Incidence and Period Seroprevalence: Results From a Statewide Population-Based Serosurvey in California.
SARS-CoV-2 Cumulative Incidence and Period Seroprevalence: Results From a Statewide Population-Based Serosurvey in California.
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DOI：
10.1093/ofid/ofab379
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发表时间：
2021-08
影响因子：
4.2
通讯作者：
Siegler AJ
中科院分区：
文献类型：
--
作者：
Lamba K;Bradley H;Shioda K;Sullivan PS;Luisi N;Hall EW;Mehrotra ML;Lim E;Jain S;Kamali A;Sanchez T;Lopman BA;Fahimi M;Siegler AJ
加利福尼亚州报告的2019年冠状病毒病(新冠肺炎)病例数量是美国各州中最多的，截至2021年3月已确诊350多万例。然而，严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在加利福尼亚州的传播范围尚不清楚，因为报告的病例只占所有感染的一小部分。我们进行了一项基于人群的血清调查，利用邮寄的、以家庭为基础的SARS-CoV-2抗体检测以及人口统计学和行为调查。我们对随机抽样的数据进行加权，以代表加利福尼亚州的成年人口和总体上估计的血清阳性率，并根据参与者的特征进行评估。对抗体减弱的血清阳性率估计进行了调整，以产生全州范围内对累积发病率、感染死亡率(IFR)和报告的比例的估计。加州2020年8月至12月的SARS-CoV-2加权血清阳性率为4.6%(95%可信区间，2.8%-7.4%)。截至2020年11月2日，估计累计发病率为8.7%(95%CRI，6.4%-11.5%)，表明2660 441名成人(95%CRI，1999218-3532380)已被感染。估计IFR为0.8%(95%CRI，0.6%-1.0%)，向加州公共卫生部报告的感染百分比估计为31%。在西班牙裔/拉丁裔人和没有医疗保险并报告外出工作的人中观察到感染的风险非常高。我们提出了第一个全州范围的SARS-CoV-2在加利福尼亚州成年人中的累积发病率估计。截至2020年11月，公共卫生监测发现，加州成年人中每3人中就有1人感染SARS-CoV-2。当考虑到未报告的SARS-CoV-2感染时，在基于病例的监测中看到的种族/民族差异仍然存在。在加利福尼亚州进行的一项基于人群的血清调查发现，到2020年11月，大约三分之一的SARS-CoV-2感染病例已被报告。按种族/民族和健康的社会决定因素划分的血清阳性率差异与在聚合酶链式反应确诊病例中看到的一致。
California has reported the largest number of coronavirus disease 2019 (COVID-19) cases of any US state, with more than 3.5 million confirmed as of March 2021. However, the full breadth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in California is unknown as reported cases only represent a fraction of all infections. We conducted a population-based serosurvey, utilizing mailed, home-based SARS-CoV-2 antibody testing along with a demographic and behavioral survey. We weighted data from a random sample to represent the adult California population and estimated period seroprevalence overall and by participant characteristics. Seroprevalence estimates were adjusted for waning antibodies to produce statewide estimates of cumulative incidence, the infection fatality ratio (IFR), and the reported fraction. California’s SARS-CoV-2 weighted seroprevalence during August–December 2020 was 4.6% (95% CI, 2.8%–7.4%). Estimated cumulative incidence as of November 2, 2020, was 8.7% (95% CrI, 6.4%–11.5%), indicating that 2 660 441 adults (95% CrI, 1 959 218–3 532 380) had been infected. The estimated IFR was 0.8% (95% CrI, 0.6%–1.0%), and the estimated percentage of infections reported to the California Department of Public Health was 31%. Disparately high risk for infection was observed among persons of Hispanic/Latinx ethnicity and people with no health insurance and who reported working outside the home. We present the first statewide SARS-CoV-2 cumulative incidence estimate among adults in California. As of November 2020, ~1 in 3 SARS-CoV-2 infections in California adults had been identified by public health surveillance. When accounting for unreported SARS-CoV-2 infections, disparities by race/ethnicity seen in case-based surveillance persist. A population-based serosurvey conducted in California found approximately one in three SARS-CoV-2 infections had been reported by November 2020. Disparities in seroprevalence by race/ethnicity and social determinants of health were consistent with those seen among PCR-confirmed cases.
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DOI：
10.1097/ede.0000000000001361
发表时间：
2021-07-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Shioda K;Lau MSY;Kraay ANM;Nelson KN;Siegler AJ;Sullivan PS;Collins MH;Weitz JS;Lopman BA
通讯作者：
Lopman BA
影响因子：
5.6
作者：
Lavange, Lisa M.;Kalsbeek, William D.;Sorlie, Paul D.;Aviles-Santa, Larissa M.;Kaplan, Robert C.;Barnhart, Janice;Liu, Kiang;Giachello, Aida;Lee, David J.;Ryan, John;Criqui, Michael H.;Elder, John P.
通讯作者：
Elder, John P.
影响因子：
3.3
作者：
Cerel, Julie;Maple, Myfanwy;Brown, Margaret
通讯作者：
Brown, Margaret
影响因子：
13.8
作者：
Chido-Amajuoyi, Onyema Greg;Yu, Robert K.;Shete, Sanjay
通讯作者：
Shete, Sanjay
影响因子：
33.9
作者：
Biggs, Holly M.;Harris, Jennifer B.;Tate, Jacqueline E.
通讯作者：
Tate, Jacqueline E.